Assessment of small sensory fiber function in myotonic dystrophy type 1

Autor:	Karl Ng, Robert Boland-Freitas
Rok vydání:	2019
Předmět:	Adult Male musculoskeletal diseases 0301 basic medicine congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Physiology Neural Conduction Sensory system Disease 030105 genetics & heredity Nerve Fibers Myelinated Myotonic dystrophy Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Physiology (medical) Internal medicine Diabetes mellitus medicine Humans Myotonic Dystrophy Thermosensing Fiber Aged Subclinical infection Nerve Fibers Unmyelinated Foot business.industry Middle Aged Hand medicine.disease medicine.anatomical_structure Case-Control Studies Sensory Thresholds Peripheral nervous system Cardiology Female Neurology (clinical) business 030217 neurology & neurosurgery Sensory nerve
Zdroj:	Muscle & Nerve. 60:575-579
ISSN:	1097-4598 0148-639X
Popis:	BACKGROUND Myotonic dystrophy type 1 (DM1) is a multisystem disorder affecting the peripheral nervous system. However, studies evaluating somatic small fiber sensory nerve function, which may contribute to pain in DM1, are lacking. METHODS Using quantitative sensory testing of the hand and foot, we evaluated Aδ and C-fiber function. Of 20 adult DM1 patients recruited, 16 were analyzed. Their results were compared with those of 32 age- and sex-matched controls. RESULTS No DM1 patient had diabetes mellitus or clinical evidence of small fiber neuropathy. In DM1, hand (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d33e461d25a0eb306c96029c51c506e https://doi.org/10.1002/mus.26673 Zobrazit plný text záznamu Plný text