Endocrine-Disrupting Chemicals and Testicular Cancer: A Case-Control Study
| Autor: | Nori, F, Carbone, P, Giordano, Felice, Osborn, John Frederick, Petritsi, Irene, Petritsi, I. |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Health Toxicology and Mutagenesis Rome Physiology Endocrine System Toxicology Logistic regression Testicular Neoplasms Risk Factors Occupational Exposure Surveys and Questionnaires medicine Humans Endocrine system Testicular cancer General Environmental Science Gynecology business.industry Public Health Environmental and Occupational Health Case-control study Environmental Exposure Seminoma Middle Aged medicine.disease Undescended testicle Low birth weight Logistic Models Case-Control Studies Etiology medicine.symptom business |
| Zdroj: | Archives of Environmental & Occupational Health. 61:87-95 |
| ISSN: | 2154-4700 1933-8244 |
| DOI: | 10.3200/aeoh.61.2.87-95 |
| Popis: | Environmental factors appear to be important in the etiology of testicular cancer. In this study, the authors identified some risk factors for testicular cancer, paying particular attention to prenatal and early life exposure to endocrine-disrupting chemicals (EDCs). Using a questionnaire, the authors obtained information on male participants' environmental and occupational exposures during adolescence and adulthood. A multivariate logistic regression analysis of 103 cases and 215 controls showed an association between seminoma and nonseminoma and hobby activities that potentially involved the use of EDCs (eg, paints, glues, or solvents). Rural residence during adolescence was associated with all histological types of testicular cancer and with seminoma. No association was found with occupational exposures of the subjects. This study's findings also confirm previously identified risk factors, such as history of cryptorchidism and undescended testicle, high educational level, and low birth weight, and it gives some support to the hypothesis of a possible association between EDC exposures and testicular cancer. |
| Databáze: | OpenAIRE |
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