The effect of endostatin evaluated in an experimental animal model of collagen‐induced arthritis

Autor:	Daitaro Kurosaka, Isamu Kingetsu, Saburo Saito, Ken Yoshida, Akio Yamada, Kazuhiro Furuya, N Yamaguchi, Jun Yasuda, Kensuke Joh, Kentaro Noda, Chiho Yasuda, Taro Ukichi
Rok vydání:	2007
Předmět:	Male Drug Endothelium media_common.quotation_subject Immunology Gene Expression Arthritis Angiogenesis Inhibitors macromolecular substances Pharmacology Mice Rheumatology medicine Animals Immunology and Allergy Collagen Type II media_common Dose-Response Relationship Drug Reverse Transcriptase Polymerase Chain Reaction business.industry General Medicine medicine.disease Endostatins Angiogenesis inhibitor Disease Models Animal Regimen Dose–response relationship Treatment Outcome medicine.anatomical_structure Mice Inbred DBA cardiovascular system Cytokines RNA Endothelium Vascular Endostatin business Biomarkers Injections Intraperitoneal Collagen-induced arthritis
Zdroj:	Scandinavian Journal of Rheumatology. 36:434-441
ISSN:	1502-7732 0300-9742
DOI:	10.1080/03009740701605913
Popis:	To investigate the arthritis-inhibiting effect of endostatin, a potent angiogenesis inhibitor, on type II collagen-induced arthritis (CIA).In an experimental system of prophylactic administration, endostatin was administered once daily at 1 mg/kg/day or 10 mg/kg/day for 2 weeks from before the onset of arthritis. In the experimental system of therapeutic administration, mice with an arthritis score of 1 to 3 were administered endostatin once daily at 10 mg/kg. In the experimental system of continuous administration, endostatin was administered using an osmotic pump capable of continuously administering a calculated dose of 1 mg/kg/day for 2 weeks.Arthritis scores were lower in a dose-dependent manner in the prophylactic administration group than in the control group. Arthritis scores were lower in the therapeutic administration group than in the control group. Compared with the once-daily dosage regimen, the administration of endostatin by an osmotic pump achieved a similar arthritis-inhibiting effect at one-tenth of the dose.Both prophylactic and therapeutic administration of endostatin inhibited type II CIA in mice. The administration method using an osmotic pump is useful.
Databáze:	OpenAIRE
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