Acute renal failure after massive ingestion of gliclazide in a suicide attempt
| Autor: | B Michittu, A. Pani, O Manca, A Barracca, Paolo Altieri, O. Ledda, G F Pili |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Suicide Attempted Critical Care and Intensive Care Medicine Gastroenterology Renal Dialysis Internal medicine Diabetes mellitus medicine Animals Humans Hypoglycemic Agents Gliclazide Chronic toxicity Dialysis Suicide attempt business.industry General Medicine Kidney Tubular Necrosis Acute medicine.disease Endocrinology Nephrology Toxicity Hemodialysis business Kidney disease medicine.drug |
| Zdroj: | Renal failure. 20(3) |
| ISSN: | 0886-022X |
| Popis: | Gliclazide, a sulfonlyurea class molecule, is used to control glycaemic levels in non-insulin-dependent diabetes mellitus. Acute and chronic toxicity studies, conducted in various animal species, have demonstrated a very low toxicity. We report a patient who developed acute renal failure due to acute tubular necrosis following a massive ingestion of gliclazide in an suicide attempt. The patient ingested 28 grams of gliclazide; the normal dose of gliclazide is 80 mg one or twice a day. At admission the patient was hypoglycaemia and in a few days became oliguric with an increase in the serum creatinine concentration, but with a normal blood urea nitrogen level. He underwent dialysis and ten days after ingestion of gliclazide, his renal function improved rapidly. |
| Databáze: | OpenAIRE |
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