Apolipoprotein A-II polymorphism: relationships to behavioural and hormonal mediators of obesity
| Autor: | Marta Garaulet, Yu-Chi Lee, Carmen Sánchez-Moreno, Jose M. Ordovas, Caren E. Smith |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism Saturated fat Medicine (miscellaneous) Overweight Article Body Mass Index Eating Weight loss Internal medicine medicine Odds Ratio Humans Obesity Analysis of Variance Nutrition and Dietetics business.industry Odds ratio Feeding Behavior medicine.disease Dietary Fats Diet Records Ghrelin Weight Reduction Programs Endocrinology Cross-Sectional Studies Logistic Models Spain Female medicine.symptom business Body mass index Apolipoprotein A-II |
| Popis: | The interaction between apolipoprotein A-II (APOA2) m265 genotype and saturated fat for obesity traits has been more extensively demonstrated than for any other locus, but behavioural and hormonal mechanisms underlying this relationship are unexplored. In this study, we evaluated relationships between APOA2 and obesity risk with particular focus on patterns of eating and ghrelin, a hormonal regulator of food intake. Cross-sectional study. Overweight and obese subjects (n=1225) were evaluated at baseline in five weight loss clinics in southeastern Spain. Behavioural data were assessed using a checklist of weight loss obstacles. Logistic regression models were fitted to estimate the risk of a specific behaviour associated with APOA2 genotype. Relationships between APOA2 genotype and saturated fat intakes for anthropometric traits and plasma ghrelin were evaluated by analysis of variance. To construct categorical variables to evaluate interactions, saturated fat intake was dichotomized into high and low according to the population median intake or as tertiles. Homozygous minor (CC) subjects were more likely to exhibit behaviours that impede weight loss (‘Do you skip meals’, odds ratio (OR)=2.09, P=0.008) and less likely to exhibit the protective behaviour of ‘Do you plan meals in advance’ (OR=0.64, P=0.034). Plasma ghrelin for CC subjects consuming low saturated fat was lower compared with (1) CC subjects consuming high saturated fat, (2) TT+TC carriers consuming low saturated fat and (3) TT+TC carriers consuming high saturated fat (all P |
| Databáze: | OpenAIRE |
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