Abnormalities in the white matter tracts in patients with Parkinson disease and psychosis
| Autor: | Jitender Saini, Lija George, Shyam Sundar Arumugham, Pramod Kumar Pal, Abhishek Lenka, Shantala Hegde, Ravi Yadav, Madhura Ingalhalikar, Apurva Shah |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Psychosis medicine.medical_specialty Audiology Corpus callosum White matter 03 medical and health sciences 0302 clinical medicine Fasciculus Fractional anisotropy medicine Humans Inferior longitudinal fasciculus Aged biology business.industry Brain Parkinson Disease Middle Aged medicine.disease biology.organism_classification White Matter 030227 psychiatry medicine.anatomical_structure Cross-Sectional Studies Diffusion Tensor Imaging nervous system Psychotic Disorders Corticospinal tract Female Neurology (clinical) business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Neurology. 94(18) |
| ISSN: | 1526-632X |
| Popis: | ObjectiveThe objective of the current study was to compare the microstructural integrity of the white matter (WM) tracts in patients having Parkinson disease (PD) with and without psychosis (PD-P and PD-NP) through diffusion tensor imaging (DTI).MethodsThis cross-sectional study involved 48 PD-NP and 42 PD-P who were matched for age, sex, and education. Tract-based spatial statistics (TBSS) was used to compare several DTI metrics from the diffusion-weighted MRIs obtained through a 3-Tesla scanner. A set of neuropsychological tests was used for the cognitive evaluation of all patients.ResultsThe severity and stage of PD were not statistically different between the groups. The PD-P group performed poorly in all the neuropsychological domains compared with the PD-NP group. TBSS analysis revealed widespread patterns of abnormality in the fractional anisotropy (FA) in the PD-P group, which also correlated with some of the cognitive scores. These tracts include inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, right parieto-occipital WM, body of the corpus callosum, and corticospinal tract.ConclusionThis study provides novel insights into the putative role of WM tract abnormalities in the pathogenesis of PD-P by demonstrating significant alterations in several WM tracts. Additional longitudinal studies are warranted to confirm the findings of our research. |
| Databáze: | OpenAIRE |
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