Classification Accuracy of Serum Apo A-I and S100B for the Diagnosis of Mild Traumatic Brain Injury and Prediction of Abnormal Initial Head Computed Tomography Scan
| Autor: | Sohug Mookerjee, Karin Kiechle, Wayne R Triner, George L. Ellis, LaLainia M. Secreti, Hua He, Brian Blyth, Susan M. Wojcik, Jawwad Khan, Ronald Moscati, August Leinhart, Ryan Moynihan, Jeffrey J. Bazarian, William D. Grant, Courtney M.C. Jones |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Traumatic brain injury S100 Calcium Binding Protein beta Subunit Sensitivity and Specificity Head trauma Injury Severity Score Predictive Value of Tests Humans Medicine Prospective Studies Child Prospective cohort study Aged Apolipoprotein A-I Receiver operating characteristic business.industry Age Factors Brain Original Articles Emergency department Middle Aged medicine.disease Confidence interval Surgery Radiography Brain Injuries Predictive value of tests Female Neurology (clinical) business Nuclear medicine |
| Zdroj: | Journal of Neurotrauma. 30:1747-1754 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2013.2853 |
| Popis: | The objective of the current study was to determine the classification accuracy of serum S100B and apolipoprotein (apoA-I) for mild traumatic brain injury (mTBI) and abnormal initial head computed tomography (CT) scan, and to identify ethnic, racial, age, and sex variation in classification accuracy. We performed a prospective, multi-centered study of 787 patients with mTBI who presented to the emergency department within 6 h of injury and 467 controls who presented to the outpatient laboratory for routine blood work. Serum was analyzed for S100B and apoA-I. The outcomes were disease status (mTBI or control) and initial head CT scan. At cutoff values defined by 90% of controls, the specificity for mTBI using S100B (0.899 [95% confidence interval (CI): 0.78–0.92]) was similar to that using apoA-I (0.902 [0.87–0.93]), and the sensitivity using S100B (0.252 [0.22–0.28]) was similar to that using apoA-I (0.249 [0.22–0.28]). The area under the receiver operating characteristic curve (AUC) for the combination of S100B and apoA-I (0.738, 95% CI: 0.71, 0.77), however, was significantly higher than the AUC for S100B alone (0.709, 95% CI: 0.68, 0.74, p=0.001) and higher than the AUC for apoA-I alone (0.645, 95% CI: 0.61, 0.68, p |
| Databáze: | OpenAIRE |
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