Antidepressant effects of the extract YZ-50 from Polygala tenuifolia in chronic mild stress treated rats and its possible mechanisms
Autor: | Dong-Xiao Wang, Dai-Hong Guo, Ting-Ting Xie, Ping Liu, Khalid Rahman, Yuan Hu |
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Rok vydání: | 2010 |
Předmět: |
Male
Polygala Drug Evaluation Preclinical Pharmaceutical Science Hippocampal formation Pharmacology Motor Activity Weight Gain Hippocampus Open field Rats Sprague-Dawley chemistry.chemical_compound Random Allocation Adrenocorticotropic Hormone Corticosterone Neurotrophic factors health services administration Drug Discovery medicine Hippocampus (mythology) Animals health care economics and organizations biology business.industry Depression Plant Extracts Brain-Derived Neurotrophic Factor General Medicine biology.organism_classification Antidepressive Agents Rats Polygalaceae Complementary and alternative medicine Mechanism of action chemistry Polygala tenuifolia Molecular Medicine Antidepressant medicine.symptom business Stress Psychological Drugs Chinese Herbal Phytotherapy |
Zdroj: | Pharmaceutical biology. 48(7) |
ISSN: | 1744-5116 |
Popis: | YZ-50 is an active fraction obtained from the root of Polygala tenuifolia Willd. (Polygalaceae) extract and it has been reported previously to exert beneficial effects on mental health in depressed sufferers, however, its mechanism of action remains unresolved. This study utilized the chronic mild stress (CMS) model of depression in Sprague-Dawley rats to evaluate the effects of YZ-50 on depressive behaviors. Furthermore, we tested the hypothesis that the capacity of YZ-50 to reverse the harmful effects of CMS is relative to the hypothalamo-pituitary-adrenal (HPA) system and brain-derived neurotrophic factor (BDNF) in the hippocampus. Repeated administration of YZ-50 for 28 days at the doses of 140 and 280 mg/kg in CMS, YZ-50 reversed the CMS-induced changes in sucrose consumption, plasma corticosterone levels and open field activity. In addition, CMS significantly decreased hippocampal BDNF mRNA levels. However, YZ-50 counteracted a decrease in hippocampal BDNF mRNA caused by CMS. In conclusion, YZ-50 reversed the harmful effects of CMS on mood and behaviors in rats and it possesses an antidepressant property that is at least in part mediated by the neuroendocrine and neuropropective systems, and it is likely that the HPA system plays an important role in this process. |
Databáze: | OpenAIRE |
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