866G/A and Ins/Del polymorphisms in UCP2 gene are associated with reduced short-term weight loss in patients who underwent Roux-en-Y gastric bypass
| Autor: | Elis Assis Rossoni, Michelle Rodrigues, Denise Alves Sortica, Rogério Friedman, Daisy Crispim, Milene Moehlecke, Jaqueline Driemeyer Correia Horvath, Natália Luiza Kops, Mayara Souza de Oliveira, Cristiane Bauermann Leitão, Mariana L.D. C. Heredia, Manoel Roberto Maciel Trindade, Jakeline Rheinheimer, Luciana Verçoza Viana, Bianca Marmontel de Souza |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Gastric Bypass 030209 endocrinology & metabolism Gastroenterology Ion Channels Body Mass Index Mitochondrial Proteins 03 medical and health sciences 0302 clinical medicine Weight loss Polymorphism (computer science) Internal medicine Genotype Weight Loss medicine Humans Uncoupling Protein 2 Longitudinal Studies Allele Retrospective Studies business.industry Haplotype medicine.disease Roux-en-Y anastomosis Obesity Surgery Obesity Morbid 030211 gastroenterology & hepatology medicine.symptom business Body mass index |
| Zdroj: | Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 17(7) |
| ISSN: | 1878-7533 |
| Popis: | Background Uncoupling protein 2 (UCP2) plays an important role in energy expenditure regulation. Previous studies have associated the common −866G/A (rs659366) and Ins/Del polymorphisms in the UCP2 gene with metabolic and obesity-related phenotypes. However, it is still unclear whether these polymorphisms influence weight loss after bariatric surgery. Objectives To investigate whether UCP2 −866G/A and Ins/Del polymorphisms are associated with weight loss outcomes after bariatric surgery. Setting Longitudinal study in a university hospital. Methods We retrospectively evaluated 186 patients who underwent Roux-en-Y gastric bypass (RYGB) surgery for clinical and laboratory characteristics in the preoperative period, 6, 12, and 18 months after RYGB. The −866G/A (rs659366) polymorphism was genotyped using real-time PCR, while the Ins/Del polymorphism was genotyped by direct separation of PCR products in 2.5% agarose gels. Results Patients with the −866A/A genotype showed higher body mass index (BMI) after 6, 12, and 18 months of surgery and excess body weight after 6 and 12 months compared with G/G patients. They also showed lower excess weight loss (EWL%) after 6 and 12 months of surgery. Ins allele carriers (Ins/Ins + Ins/Del) had lower delta (Δ) BMI 12 months after surgery compared with Del/Del patients. Accordingly, patients carrying haplotypes with ≥2 risk alleles of these polymorphisms had higher BMI and excess weight and lower EWL% during follow-up. Conclusion UCP2 −866A/A genotype is associated with higher BMI and excess weight and lower EWL% during an 18-month follow-up of patients who underwent RYGB, while the Ins allele seems to be associated with lower ΔBMI 12 months after surgery. Further studies are needed to confirm the associations of the −866G/A and Ins/Del polymorphisms with weight loss after bariatric surgery. |
| Databáze: | OpenAIRE |
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