Racial influence on the prevalence of prostate carcinoma in Brazilian volunteers
| Autor: | Marcos A Zago, Monica T. Pastorello, Antonio Carlos Pereira Martins, Kiyoko A Sândis, Wilson A. Silva, Léa Maria Zanini Maciel, Edson Luiz Paschoalin, Jose Bessa |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Gynecology
medicine.medical_specialty medicine.diagnostic_test business.industry Urology Psa density prevalence Cancer Prostate carcinoma Rectal examination medicine.disease lcsh:Diseases of the genitourinary system. Urology lcsh:RC870-923 Gastroenterology prostatic neoplasms Prostate cancer Prostate-specific antigen Internal medicine Biopsy medicine prostate-specific antigen business race Total psa |
| Zdroj: | International braz j urol v.29 n.4 2003 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU International Brazilian Journal of Urology, Vol 29, Iss 4, Pp 300-305 (2003) International braz j urol, Volume: 29, Issue: 4, Pages: 300-305, Published: AUG 2003 |
| ISSN: | 1677-5538 |
| Popis: | PURPOSE: To investigate the prevalence of prostate carcinoma in a sample of volunteers known to have a large proportion of Bantu African ancestors, and the performance of total PSA (tPSA), PSA density (PSAD) and free-to-total PSA ratio (f/tPSA) on the diagnosis. MATERIALS AND METHODS: A total of 473 volunteers (range: 40 - 79 years) were screened for prostate carcinoma. Those with tPSA >2 ng/ml and/or abnormal digital rectal examination were submitted to a transrectal ultrasound-directed biopsy (10 cores). The volunteers were classified as White, Mulatto or Black according to physical characteristics and to ancestors race reference. The following variable number of tandem repeats (VNTR) were analyzed in the blood of 120 volunteers without cancer and in 27 patients with prostate cancer: D4S43, PAH, F13A1, APOB and vW-1. RESULTS: The biopsies performed in 121 volunteers revealed cancer in 27 (5.7% of 473). The proportions of cancer in White, Mulatto and Black were respectively: 0.6% (1/148), 6.7% (6/90) and 8.5% (20/235) (p = 0.006). The VNTRs analysis revealed heterogeneity in White, Mulatto and Black anthropologic phenotypes with the following admixture of Caucasian, African and Amerindian gene lineages: 67.5 ± 8%, 20.8 ± 8%, 11.7 ± 7%; 54.8 ± 9%, 36.3 ± 5%, 8.9 ± 7%; and, 45.3 ± 3%, 45.9 ± 4%, 8.8 ± 7%. Such a mixture was 50.5 ± 9%, 49 ± 8% and 0.5 ± 4% in volunteers bearing cancer, and 59.1 ± 7%, 31.7 ± 8% and 9.2 ± 5% in those without cancer. The sensitivity and specificity of tPSA at cut-off levels of 2, 2.5 and 4 ng/ml for volunteers with tPSA |
| Databáze: | OpenAIRE |
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