The effect of cyclosporine A (Restasis) on recovery of visual acuity following LASIK
| Autor: | Tracy L. Purcell, David J. Schanzlin, Aniruddha Nalgirkar, Bryan U. Tan, Roxana Ursea, Michael R Ehrenhaus, Mario E Lovaton |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual acuity genetic structures medicine.medical_treatment Administration Topical Prednisolone Keratomileusis Laser In Situ Visual Acuity Gatifloxacin Ophthalmology medicine Myopia Effective treatment Humans In patient Glucocorticoids Aged Retrospective Studies business.industry Standard treatment LASIK Astigmatism Retrospective cohort study Eye drop Recovery of Function Middle Aged eye diseases Anti-Bacterial Agents Regimen Cyclosporine Surgery Drug Therapy Combination Female Lasers Excimer sense organs medicine.symptom business Immunosuppressive Agents Fluoroquinolones |
| Zdroj: | Journal of refractive surgery (Thorofare, N.J. : 1995). 24(5) |
| ISSN: | 1081-597X |
| Popis: | PURPOSETo compare the recovery of uncorrected visual acuity (UCVA) following LASIK in patients treated with topical cyclosporine A 0.05% and patients treated with a standard postoperative regimen. METHODSIn this single-center, open-label, retrospective study, a standard refractive workup was performed in 45 patients (85 eyes) who underwent LASIK and did not have preexisting dry eye. In 36 eyes, a standard postoperative eye drop regimen was followed, and in 49 eyes, cyclosporine A 0.05% was added to the standard regimen for 12 weeks. Uncorrected visual acuity was measured 1 week and 1 and 3 months postoperatively. RESULTSOne week postoperatively, 22 (44.9%) eyes in the cyclosporine A group and 8 (22.2%) eyes in the standard treatment group had UCVA of 20/15. Cumulatively, 36 (73.5%) eyes in the cyclosporine A group and 24 (66.7%) eyes in the standard treatment group had UCVA of 20/20 or better. One month postoperatively, 37 (75.5%) in the cyclosporine A group and 23 (63.9%) eyes in the standard treatment group had UCVA of 20/20 or better. Three months postoperatively, 40 (81.6%) eyes in the cyclosporine A group and 25 (69.4%) eyes in the standard treatment group had UCVA of 20/20 or better. Mean UCVA in the cyclosporine A group showed statistically significant improvements compared with the standard treatment group. CONCLUSIONSCyclosporine A 0.05%, in the form of Restasis, may be an effective treatment for reducing the time needed for visual recovery after LASIK. Use of cyclosporine A was associated with overall better and faster recovery of UCVA. [J Refract Surg. 2008;24:473-476.] ABOUT THE AUTHORS From the Shiley Eye Center, University of California San Diego, La Jolla, Calif. Supported in part by an unrestricted grant to the Department of Ophthalmology from Research to Prevent Blindness Inc. The authors have no proprietary interest in the materials presented herein. Correspondence: David J. Schanzlin, MD, Shiley Eye Center, University of California San Diego, 9415 Campus Point Dr, #0946, La Jolla, CA 92093-0946. Tel: 858.822.1553; Fax: 858.822.1514; E-mail: dschanzlin@ucsd.edu Received: August 17, 2006 Accepted: April 24, 2007 Posted online: October 15, 2007 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|