Implementation of intensity-modulated radiotherapy for head and neck cancers in routine practice

Autor: J.-F. Bosset, F. Tochet, O. Mauvais, C. Azélie, X.S. Sun, Juliette Thariat, T. Maurina, J. Miny, E. Bonnet, T.V.F. Nguyen, C. Bednarek, N. Lescut, M. Puyraveau
Rok vydání: 2016
Předmět:
Larynx
Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Antineoplastic Agents
Kaplan-Meier Estimate
Disease-Free Survival
030218 nuclear medicine & medical imaging
Tertiary Care Centers
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Stage (cooking)
Radiation treatment planning
Radiation Injuries
Aged
Retrospective Studies
Aged
80 and over
business.industry
Head and neck cancer
Induction chemotherapy
Retrospective cohort study
Radiotherapy Dosage
Middle Aged
medicine.disease
Prognosis
Combined Modality Therapy
Surgery
Radiation therapy
medicine.anatomical_structure
Oncology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
T-stage
Female
France
Radiotherapy
Intensity-Modulated
Neoplasm Recurrence
Local
business
Zdroj: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique. 21(1)
ISSN: 1769-6658
Popis: Purpose To report on patterns of relapse following implementation of intensity-modulated radiotherapy and subsequent changes in practice in a tertiary care centre. Patients and methods Between 2008 and 2011, 188 consecutive patients (mean age 59 years old) received intensity-modulated radiotherapies with curative intent for squamous cell carcinomas of the oral cavity (17.5%), oropharynx (43%), hypopharynx (21%), larynx (14%), sinonasal cavities (6%), nasopharynx (1.5%) at the university hospital of Besancon. There were stage I and II 9%, III 24.5%, IV 66.5%. One hundred and thirty-eight underwent exclusive intensity-modulated radiotherapy, 50 underwent postoperative intensity-modulated radiotherapy, 174 had concurrent chemotherapy, 57 had induction chemotherapy. Dynamic intensity-modulated radiotherapy with static fields was performed for all patients using sequential irradiation in 174 patients and simultaneous integrated boost irradiation in 14 patients. Results With a median follow-up was 27.5 months, there was 79% of locoregional failures occurred in the 95% isodose. Two-year overall survival, disease-free, local failure-free and locoregional failure-free survival rates were73%, 60%, 79% and 72%, respectively. Prognostic factors for disease-free survival were stage (IV vs. I–III) with a relative risk of 1.7 [1.1–2.8] (P = 0.02) and T stage with 1.6 [1.04–2.5] (P = 0.03). Conclusion The current series showed similar patterns of failure as in other tertiary care centres. We did not identify intensity-modulated radiotherapy specific relapse risks.
Databáze: OpenAIRE
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