Mechanisms that limit proliferative potential of drug‐specific LTT in drug‐induced severe cutaneous adverse reaction patients
| Autor: | Colette Goujon, Jean-Claude Roujeau, Maja Mockenhaupt, Martine Bagot, Haudrey Assier, Peggy Sekula, Sabine Le Gouvello, Laurence Valeyrie-Allanore, Nicolas Ortonne, François Berrehar, Armand Bensussan |
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| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Drug Allergy business.industry media_common.quotation_subject Sulfamethoxazole Immunology Allopurinol Carbamazepine Lamotrigine medicine.disease Toxic epidermal necrolysis stomatognathic diseases medicine Immunology and Allergy Adverse effect business medicine.drug media_common |
| Zdroj: | Clinical and Translational Allergy. 4 |
| ISSN: | 2045-7022 |
| DOI: | 10.1186/2045-7022-4-s3-o1 |
| Popis: | Background / Objective Prior use of “lymphocyte transformation test” (LTT) suggested that it was less often positive in Stevens-Johnson syndrome (SJS), Toxic Epidermal Necrolysis (TEN), than in other cutaneous reactions, with possible dependence on sampling date. We explored the possible role of inhibitory co-receptors in LTT, using well-defined groups of patients who reacted to carbamazepine (CBZ), or lamotrigine (LTG), sulfamethoxazole (SMX) and allopurinol (ALL). |
| Databáze: | OpenAIRE |
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