Twice-daily pre-mixed insulin rather than basal insulin therapy alone results in better overall glycaemic control in patients with Type 2 diabetes
| Autor: | S. Bai, J. Reviriego, B. Augendre-Ferrante, B. N. Campaigne, J. K. Malone |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty endocrine system diseases Combination therapy Endocrinology Diabetes and Metabolism medicine.medical_treatment Insulin Glargine Type 2 diabetes Weight Gain Gastroenterology Drug Administration Schedule Drug Delivery Systems Endocrinology Oral administration Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents Insulin Insulin lispro Aged Glycated Hemoglobin Cross-Over Studies Insulin Lispro Insulin glargine business.industry digestive oral and skin physiology nutritional and metabolic diseases Middle Aged medicine.disease Crossover study Hypoglycemia Metformin Circadian Rhythm Insulin Long-Acting Diabetes Mellitus Type 2 Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Diabetic Medicine. 22:374-381 |
| ISSN: | 1464-5491 0742-3071 |
| Popis: | Aims To compare the glycaemic control of an insulin lispro mixture (25% insulin lispro and 75% NPL) twice daily in combination with metformin to that of once-daily insulin glargine plus metformin in patients with Type 2 diabetes inadequately controlled with intermediate insulin, or insulin plus oral agent(s) combination therapy. Research design and methods Ninety-seven patients were randomized in a multicentre, open-label, 32-week crossover study. Primary variables evaluated: haemoglobin A1c (A1c), 2-h post-prandial blood glucose (BG), hypoglycaemia rate (episodes/patient/30 days), incidence (% patients experiencing ≥ 1 episode) of overall and nocturnal hypoglycaemia. Results At endpoint, A1c was lower with the insulin lispro mixture plus metformin compared with glargine plus metformin (7.54% ± 0.87% vs. 8.14% ± 1.03%, P |
| Databáze: | OpenAIRE |
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