Biodosimetry and assessment of radiation dose
| Autor: | Mercedes Moreno Domene, María Jesús Prieto Rodríguez, Rafael Herranz Crespo |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Cancer Research Dosimeter business.industry Radiation dose Biodosimetry Mass Casualty Review Ionizing radiation Dicentric chromosome FISH Oncology Radiology Nuclear Medicine and imaging Medicine Fish Dosimetry Translocations Radiology Nuclear Medicine and imaging Medical physics Radiology Dicentrics business |
| Zdroj: | Reports of Practical Oncology & Radiotherapy. 16(4):131-137 |
| ISSN: | 1507-1367 |
| DOI: | 10.1016/j.rpor.2011.06.003 |
| Popis: | Aim When investigating radiation accidents, it is very important to determine the exposition dose to the individuals. In the case of exposures over 1[[ce:hsp sp="0.25"/]]Gy, clinicians may expect deterministic effects arising the following weeks and months, in these cases dose estimation will help physicians in the planning of therapy. Nevertheless, for doses below 1[[ce:hsp sp="0.25"/]]Gy, biodosimetry data are important due to the risk of developing late stochastic effects. Finally, some accidental overexposures are lack of physical measurements and the only way of quantifying dose is by biological dosimetry. Background The analysis of chromosomal aberrations by different techniques is the most developed method of quantifying dose to individuals exposed to ionising radiations.[[ce:cross-refs refid="bib0005 bib0010"]] 1,2 Furthermore, the analysis of dicentric chromosomes observed in metaphases from peripheral lymphocytes is the routine technique used in case of acute exposures to assess radiation doses. Materials and methods Solid stain of chromosomes is used to determine dicentric yields for dose estimation. Fluorescence in situ hybridization (FISH) for translocations analysis is used when delayed sampling or suspected chronically irradiation dose assessment. Recommendations in technical considerations are based mainly in the IAEA Technical Report No. 405.[[ce:cross-ref refid="bib0010"]] 2 Results Experience in biological dosimetry at Gregorio Maranon General Hospital is described, including own calibration curves used for dose estimation, background studies and real cases of overexposition. Conclusion Dose assessment by biological dosimeters requires a large previous standardization work and a continuous update. Individual dose assessment involves high qualification professionals and its long time consuming, therefore requires specific Centres. For large mass casualties cooperation among specialized Institutions is needed. |
| Databáze: | OpenAIRE |
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