Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

Autor:	M. Arfan Ikram, Lukas Pirpamer, Daniel E. Vosberg, Edith Hofer, David Ames, Sandra van der Auwera-Palitschka, Zdenka Pausova, Xueqiu Jian, Henry Brodaty, André M. M. Sousa, Linda Ding, Tavia E. Evans, William S. Kremen, Jean Shin, Steven Tilley, Fabrice Crivello, Christophe Tzourio, Karen A. Mather, Peter R. Schofield, Joanna M. Wardlaw, Joshua C. Bis, Tomáš Paus, Bernard Mazoyer, Myriam Fornage, Thomas H. Mosley, Natalie Terzikhan, Nathan A. Gillespie, Hans J. Grabe, Michelle Luciano, Mathew A. Harris, Nenad Sestan, Wei Wen, Sherif Karama, Reinhold Schmidt, Shaojie Ma, Katharina Wittfeld, Lindsay B. Lewis, Arno Villringer, Hieab H.H. Adams, Sudha Seshadri, Neda Jahanshad, Jiyang Jiang, Sophie Maingault, Yasaman Saba, Qiong Yang, Frauke Beyer, Stéphanie Debette, Nicola J. Armstrong, Markus Scholz, Carol E. Franz, Margaret J. Wright, Shuo Li, Rebecca F. Gottesman, Aniket Mishra, Perminder S. Sachdev, Yash Patel, John B.J. Kwok, Anbupalam Thalamuthu, Helena Schmidt, Amaia Carrion-Castillo, Robin Bülow, Mark E. Bastin, Markus Loeffler, Ian E. Deary, Stefan Frenzel, Julian N. Trollor, Gennady V. Roshchupkin, A. Veronica Witte
Přispěvatelé:	Epidemiology, Medical Informatics, Radiology & Nuclear Medicine, Neurology, the ENIGMA Consortium, for the neuroCHARGE Working Group, the neuroCHARGE Working Group
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	rho GTP-Binding Proteins Male Aptitude Genome-wide association study brain development cortical surface area 0302 clinical medicine Form perception Intracranial volume genetics [RNA-Binding Proteins] genetics [Form Perception] Visual Cortex media_common Cerebral Cortex Aged 80 and over 0303 health sciences Principal Component Analysis Career Choice Microfilament Proteins genomeide association study RNA-Binding Proteins Gene Expression Regulation Developmental Cognition growth & development [Visual Cortex] Middle Aged medicine.anatomical_structure VINTAGE Cerebral cortex growth & development [Cerebral Cortex] Original Article Female Adult endocrine system Adolescent Cognitive Neuroscience media_common.quotation_subject tau Proteins Biology occupational aptitude 03 medical and health sciences Cellular and Molecular Neuroscience Young Adult Regional development medicine Humans ddc:610 030304 developmental biology Genetic association Aged physiology [Aptitude] genome-wide association study 9. Industry and infrastructure cortical thickness Brain Cortical Thickness Form Perception genetics [tau Proteins] genetics [rho GTP-Binding Proteins] genetics [Microfilament Proteins] Transcriptome Neuroscience 030217 neurology & neurosurgery Genome-Wide Association Study
Zdroj:	Cerebral Cortex, 30(7), 4121-4139. Oxford University Press Cerebral cortex 30(7), 4121-4139 (2020). doi:10.1093/cercor/bhaa035 Cerebral Cortex 2020, ' Global and regional development of the human cerebral cortex : Molecular architecture and occupational aptitudes ', Cerebral Cortex . https://doi.org/10.1093/cercor/bhaa035 Cereb Cortex
ISSN:	1047-3211
Popis:	We have carried out meta-analyses of genome-wide association studies (GWAS) (n = 23 784) of the first two principal components (PCs) that group together cortical regions with shared variance in their surface area. PC1 (global) captured variations of most regions, whereas PC2 (visual) was specific to the primary and secondary visual cortices. We identified a total of 18 (PC1) and 17 (PC2) independent loci, which were replicated in another 25 746 individuals. The loci of the global PC1 included those associated previously with intracranial volume and/or general cognitive function, such as MAPT and IGF2BP1. The loci of the visual PC2 included DAAM1, a key player in the planar-cell-polarity pathway. We then tested associations with occupational aptitudes and, as predicted, found that the global PC1 was associated with General Learning Ability, and the visual PC2 was associated with the Form Perception aptitude. These results suggest that interindividual variations in global and regional development of the human cerebral cortex (and its molecular architecture) cascade—albeit in a very limited manner—to behaviors as complex as the choice of one’s occupation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d226f09a8b9d01d3a3ad18d33554ba1 https://pure.eur.nl/en/publications/72d5930b-a0bc-44d8-8d56-fd3f2f98dfc8 Zobrazit plný text záznamu