Lack of prejunctional modulation of noradrenaline release by endogenous nitric oxide in guinea pig pulmonary artery
| Autor: | Beáta Sperlágh, Katalin Makó, László Domjanschitz, Attila Brassai |
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| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Arginine Guinea Pigs Endogeny In Vitro Techniques Pulmonary Artery Nitric Oxide Nitroarginine Nitric oxide Guinea pig Norepinephrine Cellular and Molecular Neuroscience Basal (phylogenetics) chemistry.chemical_compound Internal medicine medicine.artery medicine Animals Enzyme Inhibitors ATP synthase biology Cell Biology Electric Stimulation medicine.anatomical_structure Endocrinology chemistry Anesthesia Pulmonary artery cardiovascular system biology.protein Nitric Oxide Synthase |
| Zdroj: | Neurochemistry International. 41:279-283 |
| ISSN: | 0197-0186 |
| DOI: | 10.1016/s0197-0186(02)00012-8 |
| Popis: | The regulation of noradrenaline (NA) release by endogenous endothelium-derived compounds was investigated in the isolated guinea pig pulmonary artery preloaded with [ 3 H ]NA. The radioactivity uptake, the basal and electrical field stimulation (10 Hz, 2 ms, 360 shocks) evoked release of [ 3 H ]NA was similar in arteries with intact endothelium and after removal of the endothelium. The wide selectivity nitric oxide (NO) synthase inhibitor N-ω-nitro- l -arginine (100 μM) did not affect significantly the basal and stimulation-evoked release of [ 3 H ]NA in control and endothelium-denuded preparations. These results indicate that neither endogenous NO nor other compounds derived from the endothelium have substantial influence on the NA outflow from sympathetic nerves innervating the pulmonary artery. |
| Databáze: | OpenAIRE |
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