Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling

Autor:	Ajay P. Nayak, Deepak A. Deshpande, Sushrut D. Shah, Reynold A. Panettieri, Shi Pan, Taku Kambayashi, Pawan K. Sharma, Elham Javed, Raymond B. Penn, Santosh K Yadav, John M. Lim
Rok vydání:	2021
Předmět:	Pulmonary and Respiratory Medicine Diacylglycerol Kinase Contraction (grammar) Bronchoconstriction Clinical Biochemistry chemistry.chemical_element Pyrimidinones Calcium chemistry.chemical_compound Negative feedback Humans Receptor Molecular Biology Cells Cultured Diacylglycerol kinase G protein-coupled receptor Editorials Muscle Smooth Cell Biology Phosphatidic acid respiratory system respiratory tract diseases Cell biology Thiazoles chemistry Gene Knockdown Techniques GTP-Binding Protein alpha Subunits Gq-G11 Airway hormones hormone substitutes and hormone antagonists Muscle Contraction Signal Transduction
Zdroj:	American Journal of Respiratory Cell and Molecular Biology
ISSN:	1535-4989
Popis:	Exaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G protein-coupled receptors causes airway hyperresponsiveness in asthma. Activation of Gq-coupled G protein-coupled receptors leads to phospholipase C (PLC)-mediated generation of inositol triphosphate (IP
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2108e6c3b1bc5df7906046eaa13d80 https://pubmed.ncbi.nlm.nih.gov/34375574 Zobrazit plný text záznamu