The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events

Autor: Michael T. Osborne, Shady Abohashem, Nicki Naddaf, Taimur Abbasi, Hadil Zureigat, Kenechukwu Mezue, Ahmed Ghoneem, Tawseef Dar, Alexander J. Cardeiro, Nehal N. Mehta, Sanjay Rajagopalan, Zahi A. Fayad, Ahmed Tawakol
Rok vydání: 2022
Předmět:
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.
ISSN: 1532-6551
Popis: Air pollution and noise exposures individually associate with major adverse cardiovascular events (MACE) via a mechanism involving arterial inflammation (ArtI); however, their combined impact on ArtI and MACE remains unknown. We tested whether dual (vs. one or neither) exposure associates with greater ArtI and MACE risk and whether MACE risk is mediated via ArtI.Individuals (N = 474) without active cancer or known cardiovascular disease with clinicalAt baseline, 46%, 46%, and 8% were exposed to high levels of neither, one, or both pollutants; 39 experienced MACE over a median 4.1 years. Exposure to an increasing number of pollutants associated with higher ArtI (standardized β [95% CI: .195 [.052, .339], P = .008) and MACE (HR [95% CI]: 2.897 [1.818-4.615], P .001). In path analysis, ArtI partially mediated the relationship between pollutant exposures and MACE (P .05).Air pollution and transportation noise exposures contribute incrementally to ArtI and MACE. The mechanism linking dual exposure to MACE involves ArtI.
Databáze: OpenAIRE
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