Fluoroquinolone Treatment of Community-Acquired Pneumonia: A Meta-Analysis
| Autor: | John Foxworth, Paul G. Cuddy, Alan R. Salkind |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Lactams medicine.drug_class Antibiotics Population 030204 cardiovascular system & hematology 030226 pharmacology & pharmacy law.invention 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents Community-acquired pneumonia Randomized controlled trial law Internal medicine medicine Humans Pharmacology (medical) education Randomized Controlled Trials as Topic Antibacterial agent Doxycycline education.field_of_study business.industry Pneumonia medicine.disease Anti-Bacterial Agents Surgery Community-Acquired Infections Number needed to treat Macrolides business Fluoroquinolones medicine.drug |
| Zdroj: | Annals of Pharmacotherapy. 36:1938-1943 |
| ISSN: | 1542-6270 1060-0280 |
| DOI: | 10.1345/aph.1c167 |
| Popis: | OBJECTIVE: To determine the role of newer fluoroquinolones (FQs) for adults with community-acquired pneumonia (CAP) whose level of illness allows treatment with an oral antibiotic. METHODS: Meta-analysis of randomized controlled trials comparing a macrolide, β-lactam, or doxycycline antibiotic with a newer oral FQ for the treatment of CAP. RESULTS: Patients (5118), most of whom were CONCLUSIONS: The newer oral FQs showed modest therapeutic benefit compared with the studied alternative antibiotics in adults with CAP. Based on the number needed to treat from the ITT population as a measure of treatment effect, clinicians must decide whether treating 33 patients with an FQ to prevent a single therapeutic failure with another studied antibiotic warrants use of an agent from that class for an illness with a generally favorable outcome regardless of antibiotic selection, and at a time when FQ resistance may be increasing. |
| Databáze: | OpenAIRE |
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