| Autor: |
Sanqi An, Zhouhua Xie, Yanyan Liao, Junjun Jiang, Wenyi Dong, Fuqiang Yin, Wen-Xing Li, Li Ye, Jianyan Lin, Hao Liang |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Genes & Diseases |
| ISSN: |
2352-3042 |
| DOI: |
10.1016/j.gendis.2021.12.005 |
| Popis: |
The outbreak of coronavirus disease 2019 (COVID-19) has affected more than 200 countries and regions to date. mRNA m6A methylation has been reported as a new therapeutic target in COVID-19 patients, and has received widespread attention. However, the effects of m6A on COVID-19 clinical features as well as the molecular characterization of m6A in real COVID-19 patients are largely unclear. We collected RNA-seq data and clinical data from 100 COVID-19 patients, and sequenced m6A-seq from peripheral blood mononuclear cells (PBMCs) of two COVID-19 patients. Using bioinformatics analysis, we found that m6A is associated with several clinical features of COVID-19 patients. Furthermore, molecular characterization of m6A of COVID-19 patients in vivo rather than cell lines is demonstrated for the first time. Our findings will be valuable for the development of novel treatment strategies for COVID-19 patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
