| Autor: |
M.J.D. Eenink, W. Potman, W.A.R. Heeswijk, T. Stoffer, Jan Feijen, C.J.T. Hoes |
| Přispěvatelé: |
Faculty of Science and Technology, Biomaterials Science and Technology |
| Jazyk: |
angličtina |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Journal of controlled release, 1(4), 301-315. Elsevier |
| ISSN: |
0168-3659 |
| DOI: |
10.1016/0168-3659(85)90006-9 |
| Popis: |
Poly(α-l-glutamic acid) (PGA) was grafted with amino acid and oligopeptide spacers up to 5 amino acids with the use of N,N'-carbonyldiimidazole and 2,3-dihydro-1,2-benz-isothiazole-3-on-1, 1-dioxide (saccharin) as an additive, and these polypeptides were characterized. The antitumor antibiotic adriamycin was covalently coupled via an amide bond onto PGA and onto the grafted polymers with the use of N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ); these conjugates were characterized. The conjugates containing Gly—Gly—l-Leu spacer arms did yield free adriamycin upon digestion with papain. Adriamycin gave fairly stable complexes with PGA—adriamycin and branched poly peptide—adriamycin conjugates; these complexes were characterized. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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