Development of High-Grade B-Cell Lymphoma Concurrent with T-Cell Chronic Lymphocytic Leukemia in a Dog
| Autor: | Masaru Okuda, Yuko Wada, Kazuhito Itamoto, Takuya Mizuno, Kenji Baba, Takumi Okawa, Hiroko Hiraoka |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Pathology medicine.medical_specialty Leukemia T-Cell Lymphoma B-Cell Lymphocytosis Chronic lymphocytic leukemia medicine.medical_treatment Dogs Fatal Outcome immune system diseases T-cell chronic lymphocytic leukemia hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols Animals Medicine Dog Diseases Chemotherapy General Veterinary business.industry High grade B-cell lymphoma medicine.disease Lymphoma Leukemia Lymph medicine.symptom business |
| Zdroj: | Journal of Veterinary Medical Science. 74:677-680 |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.11-0453 |
| Popis: | Second malignancies are frequent complications in human patients with chronic lymphocytic leukemia (CLL). However, the clinical details and outcome of this phenomenon were unclear in their canine counterparts. Here, we report a dog with high-grade lymphoma concurrent with T-cell CLL. A 10-year-old male golden retriever presented with lymphadenopathies. The lymph nodes contained large-sized lymphocytes, raising suspicion of high-grade lymphoma. Meanwhile, small lymphocytic lymphocytosis in the peripheral blood was consistent with CLL. Interestingly, molecular biological analyses revealed that CLL cells were of the T-cell type, whereas lymphoma cells were of the B-cell type. Chemotherapy using the L-VCA short protocol was effective for 155 days, but the dog died on day 194 after diagnosis, despite rescue therapies. |
| Databáze: | OpenAIRE |
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