Genetic and epigenetic risks of assisted reproduction
| Autor: | Guo-Lian Ding, He-Feng Huang, Zi-Ru Jiang, Yinyu Wang, Jing Lin, Jing-Jing Xu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Reproductive Techniques Assisted Offspring medicine.medical_treatment Fertilization in Vitro Biology Preimplantation genetic diagnosis Intracytoplasmic sperm injection Epigenesis Genetic Andrology 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors medicine Animals Humans Preimplantation Diagnosis Cryopreservation 030219 obstetrics & reproductive medicine Assisted reproductive technology Obstetrics and Gynecology Embryo General Medicine medicine.disease Embryo Transfer Embryo transfer 030104 developmental biology medicine.anatomical_structure Infertility embryonic structures Gamete Female |
| Zdroj: | Best practiceresearch. Clinical obstetricsgynaecology. 44 |
| ISSN: | 1532-1932 |
| Popis: | Assisted reproductive technology (ART) is used primarily for infertility treatments to achieve pregnancy and involves procedures such as in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), and cryopreservation. Moreover, preimplantation genetic diagnosis (PGD) of ART is used in couples for genetic reasons. In ART treatments, gametes and zygotes are exposed to a series of non-physiological processes and culture media. Although the majority of children born with this treatment are healthy, some concerns remain regarding the safety of this technology. Animal studies and follow-up studies of ART-borne children suggested that ART was associated with an increased incidence of genetic, physical, or developmental abnormalities, although there are also observations that contradict these findings. As IVF, ICSI, frozen-thawed embryo transfer, and PGD manipulate gametes and embryo at a time that is important for reprogramming, they may affect epigenetic stability, leading to gamete/embryo origins of adult diseases. In fact, ART offspring have been reported to have an increased risk of gamete/embryo origins of adult diseases, such as early-onset diabetes, cardiovascular disease, and so on. In this review, we will discuss evidence related to genetic, especially epigenetic, risks of assisted reproduction. |
| Databáze: | OpenAIRE |
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