Growth Hormone and Insulin-Like Growth Factor Dysregulation in Pediatric Chronic Kidney Disease
| Autor: | Andrew Dauber, Denver D Brown |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Population Short stature Insulin-like growth factor Endocrinology Internal medicine Humans Medicine Insulin-Like Growth Factor I Renal Insufficiency Chronic Child education education.field_of_study Human Growth Hormone business.industry Growth factor Metabolic acidosis medicine.disease Pediatrics Perinatology and Child Health Etiology medicine.symptom business Hormone Kidney disease |
| Zdroj: | Hormone Research in Paediatrics. 94:105-114 |
| ISSN: | 1663-2826 1663-2818 |
| DOI: | 10.1159/000516558 |
| Popis: | Poor growth is a common finding in children with chronic kidney disease (CKD) that has been associated with poor long-term outcomes. The etiology of poor growth in this population is multifactorial and includes dysregulation of the growth hormone (GH) and insulin-like growth factor (IGF) axis. In this review, we describe the data on GH resistance or insensitivity and inappropriate levels or reduced bioactivity of IGF proposed as contributing factors of growth impairment in children with CKD. Additionally, we describe the theorized negative effect of metabolic acidosis, another frequent finding in pediatric CKD, on the GH/IGF axis and growth. Last, we present the current and potential therapies for the treatment of short stature in pediatric CKD that target the GH/IGF hormonal axis. |
| Databáze: | OpenAIRE |
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