Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case-Control Study

Autor: Maria Dolores Hernández-Almaguer, Laura Elia Martínez-de-Villarreal, Donato Saldívar-Rodríguez, Luis Daniel Campos-Acevedo, Patricia R. Ancer-Rodríguez, Sandra M. González-Peña, Geovana Calvo-Anguiano, Melissa Calzada-Dávila, José de Jesús Lugo-Trampe, Ligia S Guerrero-Orjuela
Rok vydání: 2021
Předmět:
0301 basic medicine
Heart Septal Defects
Ventricular
Male
Physiology
030204 cardiovascular system & hematology
TBX20
Epigenesis
Genetic
folic acid intake
0302 clinical medicine
Pregnancy
AXIN1
Medicine
TX341-641
Prospective Studies
Child
Nutrition and Dietetics
biology
methylation status
TBX1
Methylation
congenital heart disease
Muscle Spasticity
DNA methylation
Female
Homocystinuria
Heart Defects
Congenital
ventricular septal defects
Article
03 medical and health sciences
Folic Acid
Humans
Genetic Predisposition to Disease
Gene
Genetic Association Studies
Methylenetetrahydrofolate Reductase (NADPH2)
business.industry
Nutrition. Foods and food supply
Case-control study
Promoter
DNA Methylation
medicine.disease
Diet
030104 developmental biology
Psychotic Disorders
Methylenetetrahydrofolate reductase
Case-Control Studies
MTHFR
Dietary Supplements
biology.protein
business
Food Science
Zdroj: Nutrients, Vol 13, Iss 2071, p 2071 (2021)
Nutrients
Volume 13
Issue 6
ISSN: 2072-6643
Popis: Background: DNA methylation is the best epigenetic mechanism for explaining the interactions between nutrients and genes involved in intrauterine growth and development programming. A possible contributor of methylation abnormalities to congenital heart disease is the folate methylation regulatory pathway
however, the mechanisms and methylation patterns of VSD-associated genes are not fully understood. Objective: To determine if maternal dietary intake of folic acid (FA) is related to the methylation status (MS) of VSD-associated genes (AXIN1, MTHFR, TBX1, and TBX20). Methods: Prospective case–control study
48 mothers and their children were evaluated. The mothers’ dietary variables were collected through a food frequency questionnaire focusing on FA and the consumption of supplements with FA. The MS of promoters of genes was determined in the children. Results: The intake of FA supplements was significantly higher in the control mothers. In terms of maternal folic acid consumption, significant differences were found in the first trimester of pregnancy. Significant differences were observed in the MS of MTHFR and AXIN1 genes in VSD and control children. A correlation between maternal FA supplementation and MS of AXIN1 and TBX20 genes was found in control and VSD children, respectively. Conclusions: A lower MS of AXIN1 genes and a higher MS of TBX20 genes is associated with FA maternal supplementation.
Databáze: OpenAIRE
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