Combination Emtricitabine and Tenofovir Disoproxil Fumarate Prevents Vaginal Simian/Human Immunodeficiency Virus Infection in Macaques Harboring Chlamydia trachomatis and Trichomonas vaginalis
| Autor: | Jessica Radzio, Ellen N. Kersh, Leecresia Jenkins, John R. Papp, Walid Heneine, Susan Kuklenyik, Shanon Ellis, Carol E. Farshy, J. Gerardo García-Lerma, Tara Henning, Janet M. McNicholl, Chuong Dinh, Angela Holder, Debra L. Hanson, Christi Phillips |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Anti-HIV Agents Simian Acquired Immunodeficiency Syndrome Chlamydia trachomatis HIV Infections Simian medicine.disease_cause Emtricitabine Macaque 03 medical and health sciences Pre-exposure prophylaxis Major Articles and Brief Reports 0302 clinical medicine Trichomonas Vaginitis biology.animal medicine Immunology and Allergy Animals Humans 030212 general & internal medicine biology business.industry Coinfection Emtricitabine Tenofovir Disoproxil Fumarate Drug Combination Chlamydia Infections medicine.disease biology.organism_classification Virology Macaca mulatta Disease Models Animal 030104 developmental biology Infectious Diseases Vagina Trichomonas vaginalis Female Pre-Exposure Prophylaxis business medicine.drug |
| Zdroj: | The Journal of infectious diseases. 213(10) |
| ISSN: | 1537-6613 |
| Popis: | Genital inflammation associated with sexually transmitted infections increases susceptibility to human immunodeficiency virus (HIV), but it is unclear whether the increased risk can reduce the efficacy of pre-exposure prophylaxis (PrEP). We investigated whether coinfection of macaques with Chlamydia trachomatis and Trichomonas vaginalis decreases the prophylactic efficacy of oral emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF). Macaques were exposed to simian/human immunodeficiency virus (SHIV) vaginally each week for up to 16 weeks and received placebo or FTC/TDF pericoitally. All animals in the placebo group were infected with SHIV, while 4 of 6 PrEP recipients remained uninfected (P = .03). Oral FTC/TDF maintains efficacy in a macaque model of sexually transmitted coinfection, although the infection of 2 macaques signals a modest loss of PrEP activity. |
| Databáze: | OpenAIRE |
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