Assessment of myocardial fibrosis by late gadolinium enhancement imaging and biomarkers of collagen metabolism in chronic rheumatic mitral regurgitation
| Autor: | Ruchika Meel, Ferande Peters, Elena Libhaber, Mohammed R. Essop, Therese Dix-Peek, Richard Nethononda |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Gadolinium DTPA
Male Contrast Media Gadolinium 030204 cardiovascular system & hematology Gastroenterology Ventricular Function Left 030218 nuclear medicine & medical imaging 0302 clinical medicine Fibrosis chronic rheumatic mitral regurgitation Prospective Studies Prospective cohort study Ventricular Remodeling medicine.diagnostic_test Mitral Valve Insufficiency General Medicine Middle Aged Magnetic Resonance Imaging Editorial late gadolinium enhancement Predictive value of tests Female Collagen Matrix Metalloproteinase 1 Cardiology and Cardiovascular Medicine Procollagen Adult medicine.medical_specialty Collagen Type I cardiac magnetic resonance Young Adult 03 medical and health sciences Predictive Value of Tests Cardiac magnetic resonance imaging Internal medicine medicine Humans Ventricular remodeling Tissue Inhibitor of Metalloproteinase-1 business.industry Myocardium Cardiovascular Topics Rheumatic Heart Disease biomarkers Magnetic resonance imaging medicine.disease Peptide Fragments Procollagen peptidase Cross-Sectional Studies Chronic Disease Myocardial fibrosis Peptides business |
| Zdroj: | Cardiovascular Journal of Africa |
| ISSN: | 1680-0745 1995-1892 |
| Popis: | Background In chronic rheumatic mitral regurgitation (CRMR), involvement of the myocardium in the rheumatic process has been controversial. Therefore, we sought to study the presence of fibrosis using late gadolinium enhancement cardiac magnetic resonance imaging (LGE-CMR) and biomarkers of collagen turnover in CRMR. Methods Twenty-two patients with CRMR underwent CMR and echocardiography. Serum concentrations of matrix metalloproteinase- 1 (MMP-1), tissue inhibitor of MMP-1 (TIMP- 1), MMP-1-to-TIMP-1 ratio, procollagen III N-terminal pro-peptide (PIIINP) and procollagen type IC peptide (PIP) were measured. Results Four patients had fibrosis on LGE-CMR. PICP and PIIINP concentrations were similar to those of the controls, however MMP-1 concentration was increased compared to that of the controls (log MMP-1 3.5 ± 0.7 vs 2.7 ± 0.9, p = 0.02). There was increased MMP-1 activity as the MMP-1-to- TIMP-1 ratio was higher in CRMR patients compared to the controls ( -1.2 ± 0.6 vs -2.1 ± 0.89, p = 0.002). Conclusions Myocardial fibrosis was rare in CRMR patients. CRMR is likely a disease characterised by the predominance of collagen degradation rather than increased synthesis and myocardial fibrosis. |
| Databáze: | OpenAIRE |
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