Microwave-assisted synthesis of cyclopentanones using the relevant phosphorus ylides
| Autor: | Faramarz Rostami-Charati, Ali Jafari, Abodolreza Yazdani, Zinatossadat Hossaini, Majid Moradian |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Models Molecular Chemistry Phosphorus Organic Chemistry chemistry.chemical_element General Medicine Cyclopentanes Cyclopentanone Crystallography X-Ray Microwave assisted Computer Science Applications Acetoacetates chemistry.chemical_compound Organophosphorus Compounds Ylide Drug Discovery Organic chemistry Combinatorial Chemistry Techniques Enantiomer Triphenylphosphine Acetylenic Compounds Microwaves |
| Zdroj: | Combinatorial chemistryhigh throughput screening. 15(4) |
| ISSN: | 1875-5402 |
| Popis: | A one-pot synthesis of cyclopentanone derivatives from phosphorus ylide under lab-type microwave assisted methodology was described. The phosphorus ylides were obtained via the reaction of activated acetylenic compounds, ethyl 4-chloroacetoacetate and triphenylphosphine. The structure of phosphorus ylides was assigned by 1H, 13C and 31PNMR. The phosphorus ylides as precursor were crystallized as two enantiomers (R,R) and (S,S) and one of the phosphorus ylide structures was confirmed by single X-ray crystallography. |
| Databáze: | OpenAIRE |
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