Decrease of plasma cholesterol with the marine microalga Dunaliella tertiolecta in hyper cholesterolemic rats
| Autor: | Estrella Vecino, Concepción Herrero, José Manuel Paz, Jaime Fábregas, Ana Otero, Yolanda Gamallo |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Hypercholesterolemic
Cholesterol Diet therapy Linoleic acid Marine microalga Plasma cholesterol Blood lipids Biology Applied Microbiology and Biotechnology Microbiology Diet Excretion chemistry.chemical_compound Biochemistry chemistry Casein Dunaliella tertiolecta Blood plasma Arachidonic acid Food science Female Sprague-Dawley rats |
| Zdroj: | RUC. Repositorio da Universidade da Coruña instname |
| ISSN: | 1349-8037 0022-1260 |
| Popis: | Female Sprague-Dawley rats, whose plasma cholesterol level had been previously increased, were fed on a diet including 22% biomass of the marine microalga Dunaliella tertiolecta. This diet was compared to two control diets, one of casein and the other of soy flour. After 14 days of feeding, the group fed the microalgal diet exhibited the largest decrease in the plasma cholesterol concentration. The plasma cholesterol level in the group fed the microalgal diet was 45.2% of that in the control group (casein diet) and 28.4% lower than the group fed the soy flour diet. These results suggest that the marine microalga Dunaliella tertiolecta has marked anti-hypercholesterolemic activity when incorporated into the diet. High levels of cholesterol in the blood are a known risk factor for the development of atherosclerosis. High levels of cholesterol in plasma can accelerate the development of arterial disease by increasing the amount of circulating lipids available for incorporation into the arterial walls (29). Diets rich in poly unsaturated fatty acids reportedly reduce serum lipids by enhancing their excretion, increase membrane fluidity and reduce thrombosis by conversion of the lipids to eicosanoids (9,14,15). Lipid-lowering diets have mainly been based on an increase of linoleic acid (18 : 2 n-6) content, but the metabolites of linoleic acid (gamma-linolenic acid, 18: 3 n-6, and arachidonic acid, 20: 4 n-6) have a much greater anti-hyper choles terolemic activity than the parent molecule (16,27). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|