A new β-hydroxydihydrochalcone from Tephrosia uniflora, and the revision of three β--hydroxydihydrochalcones to flavanones

Autor:	Carolyne Chepkirui, Catarina Bourgard, Pieter J. Gilissen, Albert Ndakala, Solomon Derese, Yukino Gütlin, Máté Erdélyi, Abiy Yenesew
Rok vydání:	2022
Předmět:	Pharmacology History Organisk kemi Polymers and Plastics Molecular Structure Plant Extracts Organic Chemistry General Medicine Gram-Positive Bacteria Industrial and Manufacturing Engineering Flavanones Drug Discovery Tephrosia Humans Business and International Management Physical Organic Chemistry
Zdroj:	Fitoterapia, 158, pp. 1-6 Fitoterapia, 158, 1-6
ISSN:	0367-326X
Popis:	The CH2Cl2/MeOH (1:1) extract of the stems of Tephrosia uniflora yielded the new β-hydroxydihydrochalcone (S)-elatadihydrochalcone-2'-methyl ether (1) along with the three known compounds elongatin (2), (S)-elatadihydrochalcone (3), and tephrosin (4). The structures were elucidated by NMR spectroscopic and mass spectrometric data analyses. Elongatin (2) showed moderate antibacterial activity (EC50 of 25.3 μM and EC90 of 32.8 μM) against the Gram-positive bacterium Bacilus subtilis, and comparable toxicity against the MCF-7 human breast cancer cell line (EC50 of 41.3 μM). Based on the comparison of literature and predicted NMR data with that obtained experimentally, we propose the revision of the structures of three β-hydroxydihydrochalcones to flavanones.
Databáze:	OpenAIRE
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