Longitudinal performance evaluation and validation of fixed-flexion radiography of the knee for detection of joint space loss
| Autor: | Charles Peterfy, Hepei Chen, Tamara B. Harris, Jeff Duryea, David T. Felson, Michael C. Nevitt, Thasia G. Woodworth, Kent Kwoh, Ali Guermazi |
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| Rok vydání: | 2007 |
| Předmět: |
musculoskeletal diseases
Male medicine.medical_specialty Knee Joint Radiography Immunology Osteoarthritis Sensitivity and Specificity Rheumatology Internal medicine Arthropathy medicine Immunology and Allergy Fluoroscopy Humans Pharmacology (medical) Longitudinal Studies Arthrography Aged medicine.diagnostic_test business.industry Reproducibility of Results Magnetic resonance imaging Osteoarthritis Knee musculoskeletal system medicine.disease Magnetic Resonance Imaging Knee pain Disease Progression Female Radiology medicine.symptom business Nuclear medicine Algorithms |
| Zdroj: | Arthritis and rheumatism. 56(5) |
| ISSN: | 0004-3591 |
| Popis: | Objective The ability of nonfluoroscopically guided radiography of the knee to assess joint space loss is an important issue in studies of progression and treatment of knee osteoarthritis (OA), given the practical limitations of protocols involving fluoroscopically guided radiography of the knee. We evaluated the ability of the nonfluoroscopically guided fixed-flexion radiography protocol to detect knee joint space loss over 3 years. Methods We assessed the same-day test–retest precision for measuring minimum joint space width (JSW), the sensitivity for detection of joint space loss using serial films obtained a median of 37 months (range 23–47 months) apart, and the relationship of joint space loss to radiographic and magnetic resonance imaging (MRI) measures of knee OA. Participants were men and women (ages 70–79 years) with knee pain who were participating in the Health, Aging, and Body Composition Study. We assessed baseline radiographic OA and measured JSW using a computerized algorithm. Serial knee MRIs obtained over the same interval were evaluated for cartilage lesions. Results A total of 153 knees were studied, 35% of which had radiographic OA at baseline. The mean ± SD joint space loss for all knees over 3 years was 0.24 ± 0.59 mm (P < 0.001 for change). In knees with OA at baseline, the mean ± SD joint space loss over 3 years was 0.43 ± 0.66 mm (P < 0.001), and in knees with joint space narrowing at baseline, joint space loss was 0.50 ± 0.67 mm (P < 0.001). Joint space loss and its standardized response mean increased with the severity of baseline joint space narrowing and with the presence of cartilage lesions at baseline and worsening during followup. Conclusion Radiography of the knee in the fixed-flexion view provides a sensitive and valid measure of joint space loss in multiyear longitudinal studies of knee OA, without the use of fluoroscopy to aid knee positioning. |
| Databáze: | OpenAIRE |
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