Distinct recruitment of basolateral amygdala-medial prefrontal cortex pathways across Pavlovian appetitive conditioning
| Autor: | Gorica D. Petrovich, Sara E. Keefer |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Cognitive Neuroscience
Conditioning Classical Infralimbic cortex Prefrontal Cortex Experimental and Cognitive Psychology Amygdala Article 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Neural Pathways medicine Animals 0501 psychology and cognitive sciences 050102 behavioral science & comparative psychology Prefrontal cortex Sensory cue Neurons Basolateral Nuclear Complex 05 social sciences Association Learning Rats Associative learning Neuroanatomical Tract-Tracing Techniques medicine.anatomical_structure Acoustic Stimulation Food Forebrain Cues Psychology Neuroscience Nucleus 030217 neurology & neurosurgery Basolateral amygdala |
| Zdroj: | Neurobiology of Learning and Memory. 141:27-32 |
| ISSN: | 1074-7427 |
| DOI: | 10.1016/j.nlm.2017.03.006 |
| Popis: | Associative learning can enable environmental cues to signal food and stimulate feeding, independent of physiological hunger. Two forebrain regions necessary in cue driven feeding, the basolateral area of the amygdala and the medial prefrontal cortex, communicate via extensive, topographically organized connections. The basolateral nucleus (BLA) sends extensive projections to the prelimbic cortex (PL), and our aim here was to determine if this pathway was selectively recruited during cue-food associative learning. The anterior and posterior basolateral nuclei are recruited during different phases of cue-food learning, and thus we examined whether distinct pathways that originate in these nuclei and project to the PL are differently recruited during early and late stages of learning. To accomplish this we used neuroanatomical tract tracing combined with the detection of Fos induction. To identify projecting neurons within the BLA, prior to training, rats received a retrograde tracer, Fluoro-Gold (FG) into the PL. Rats were given either one or ten sessions of tone-food presentations (Paired group) or tone-only presentations (Control group). The Paired group learned the tone-food association quickly and robustly and had greater Fos induction within the anterior and posterior BLA during early and late learning compared to the Control group. Notably, the Paired group had more double-labeled neurons (FG + Fos) during late training compared to the Control group, specifically in the anterior BLA. This demonstrates selective recruitment of the anterior BLA-PL pathway by late cue-food learning. These findings indicate plasticity and specificity in the BLA-PL pathways across cue-food associative learning. |
| Databáze: | OpenAIRE |
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