Biomarkers as predictors of mortality in critically ill patients with solid tumors
| Autor: | Ana Valeria Goncalves Fruchtenicht, Luis Fernando Moreira, Audrey Machado dos Reis, Luiza C. De Athaydes, Sergio Henrique Loss |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Cross-sectional study Critical Illness Disease law.invention Sepsis 03 medical and health sciences biochemical markers 0302 clinical medicine intensive care mortality Predictive Value of Tests law Neoplasms Intensive care Internal medicine Biomarkers Tumor medicine Humans Prospective Studies critically ill cancer patient lcsh:Science Prospective cohort study intensive care Multidisciplinary business.industry Medical record 030208 emergency & critical care medicine Middle Aged Prognosis medicine.disease Intensive care unit Intensive Care Units Cross-Sectional Studies 030220 oncology & carcinogenesis Predictive value of tests Female lcsh:Q business |
| Zdroj: | Anais da Academia Brasileira de Ciências, Vol 89, Iss 4, Pp 2921-2929 (2017) Anais da Academia Brasileira de Ciências, Volume: 89, Issue: 4, Pages: 2921-2929, Published: 11 DEC 2017 Anais da Academia Brasileira de Ciências v.89 n.4 2017 Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências (ABC) instacron:ABC |
| ISSN: | 1678-2690 0001-3765 |
| DOI: | 10.1590/0001-3765201720170601 |
| Popis: | Biochemical markers produced by the affected organ or body in response to disease have gained high clinical value due to assess disease development and being excellent predictors of morbidity and mortality. The aim of this study is to analyze different biochemical markers in critically cancer patients and to determine which of them can be used as predictors of mortality. This is a prospective, cross-sectional study conducted at a University Hospital in Porto Alegre - RS. Screening was done to include patients in the study. Serum biochemical markers obtained in the first 24 hours of Intensive Care Unit hospitalization were analyzed. A second review of medical records occurred after three months objected to identify death or Unit discharged. A sample of 130 individuals was obtained (control group n = 65, study group n = 65). In the multivariate model, serum magnesium values OR = 3.97 (1.17; 13.5), presence of neoplasia OR = 2.68 (95% CI 1.13; 6.37) and absence of sepsis OR = 0.31 (95% CI 0.12; 0.79) were robust predictors of mortality. The association of solid tumors, sepsis presence and alteration in serum magnesium levels resulted in an increased chance of mortality in critically ill patients. |
| Databáze: | OpenAIRE |
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