Prognostic Value of Combination of Cardiac Troponin T and B-Type Natriuretic Peptide after Initiation of Treatment in Patients with Chronic Heart Failure
| Autor: | Hiroyuki Naruse, Hitoshi Hishida, Youichi Nagamura, Wei Cui, Kouji Ezaki, Fumihiko Kitagawa, Junnichi Ishii, Yoshihisa Mori, Hisaji Oshima, Takeshi Kondo, Yuu Nakamura, Masanori Nomura, Takashi Ishikawa, Takahiro Kuno |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Heart disease medicine.drug_class Clinical Biochemistry Patient Readmission Risk Assessment Ventricular Function Left Troponin T Troponin complex Predictive Value of Tests Internal medicine Natriuretic Peptide Brain Troponin I medicine Natriuretic peptide Humans Prospective Studies cardiovascular diseases Aged Heart Failure Ejection fraction biology business.industry Biochemistry (medical) Brain natriuretic peptide medicine.disease Troponin Endocrinology Heart failure Chronic Disease cardiovascular system biology.protein Cardiology Female business Biomarkers circulatory and respiratory physiology |
| Zdroj: | Clinical Chemistry. 49:2020-2026 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1373/clinchem.2003.021311 |
| Popis: | Background: Recent studies have suggested that cardiac troponin T (cTnT) and troponin I may detect ongoing myocardial damage involved in the progression of chronic heart failure (CHF). This study was prospectively designed to examine whether the combination of cTnT, a marker for ongoing myocardial damage, and B-type natriuretic peptide (BNP), a marker for left ventricular overload, would effectively stratify patients with CHF after initiation of treatment.Methods: We measured serum cTnT, plasma BNP, and left ventricular ejection fraction (LVEF) on admission for worsening CHF [New York Heart Association (NYHA) functional class III to IV] and 2 months after initiation of treatment to stabilize CHF (n = 100; mean age, 68 years).Results: Mean (SD) concentrations of cTnT [0.023 (0.066) vs 0.063 (0.20) μg/L] and BNP [249 (276) vs 753 (598) ng/L], percentage increased cTnT (>0.01 μg/L; 35% vs 60%), NYHA functional class [2.5 (0.6) vs 3.5 (5)], and LVEF [43 (13)% vs 36 (12)%] were significantly (P 0.01 μg/L and/or BNP >160 ng/L 2 months after initiation of treatment were associated with increased cardiac mortality and morbidity rates.Conclusion: The combination of cTnT and BNP measurements after initiation of treatment may be highly effective for risk stratification in patients with CHF. |
| Databáze: | OpenAIRE |
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