A possible role of a nonadrenergic inhibitory nervous system in airway hyperreactivity
| Autor: | Mariko Domae, Takahito Hirose, Hisamichi Aizawa, Nobuaki Shigematsu, Yoshikazu Matsuzaki, Kenzo Tanaka, Masayoshi Ishibashi |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Atropine
Male Pulmonary and Respiratory Medicine Nervous system Serotonin medicine.medical_specialty Physiology Respiratory System Stimulation Propranolol Nervous System chemistry.chemical_compound Internal medicine Respiratory Hypersensitivity Animals Medicine Lung Compliance CATS business.industry Airway Resistance Neural Inhibition Vagus Nerve Electric Stimulation Vagus nerve Endocrinology medicine.anatomical_structure chemistry Cats Female Hexamethonium Airway business medicine.drug |
| Zdroj: | Respiration Physiology. 50:187-196 |
| ISSN: | 0034-5687 |
| Popis: | To investigate a possible role of a nonadrenergic inhibitory nervous system in airway hyperreactivity, we measured changes in R l and C l caused by electrical stimulation of cervical vagus nerve during the infusion of 5-HT, after treatment with atropine and propranolol in 18 cats. R l decreased to 56 ± 3% (mean ± SE) and C l increased to 186 ± 13% of the prestimulated values, respectively, after stimulation. Hexamethonium diminished these responses significantly. Airway reactivity to 5-HT was reduced by continuous electrical stimulation of cervical vagus nerve in cats pretreated with atropine and propranolol. Hexamethonium potentiated airway reactivity to 5-HT. These results suggest that a nonadrenergic inhibitory nervous system could play an important role in the control of the bronchomotor tone and contribute to airway hyperreactivity. |
| Databáze: | OpenAIRE |
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