| Autor: |
Zonghan Yang, Veerababurao Kavala, Chia Yu Huang, Chun Wei Kuo, Ching Fa Yao, Ashok Konala |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
The Journal of organic chemistry. 82(14) |
| ISSN: |
1520-6904 |
| Popis: |
An efficient approach for the synthesis of benzo-fused pyridoindolone derivatives via a one-pot copper catalyzed tandem reaction of 2-iodobenzamides with 2-iodobenzylcyanides has been developed. Using this protocol, benzo-fused pyridoindolone derivatives are obtained in high yields in a relatively short period of time under mild reaction conditions. To the best of our knowledge, this is the first approach where one can synthesize free indole N–H benzo-fused pyridoindolones. Also, both indole and pyridone cores are constructed during the course of the reaction. The methodology shows good functional group tolerance and allows synthesis of thiophene-fused pyridoindolones and fused indolobenzonaphthyridone derivatives. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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