Variability in Human Cone Topography Assessed by Adaptive Optics Scanning Laser Ophthalmoscopy
| Autor: | Russell Griffin, Yuhua Zhang, Xiaolin Wang, Pooja Godara, Tianjiao Zhang, Christine A. Curcio, Ernesto Blanco |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Fovea Centralis Visual acuity genetic structures Visual Acuity Cell Count Retinal Cone Photoreceptor Cells Foveola Article Ophthalmoscopy Young Adult Foveal medicine Humans Dioptre Physics medicine.diagnostic_test Fovea centralis Reproducibility of Results Anatomy eye diseases Healthy Volunteers Scanning laser ophthalmoscopy Ophthalmology medicine.anatomical_structure Female sense organs medicine.symptom Tomography Optical Coherence |
| Zdroj: | American journal of ophthalmology. 160(2) |
| ISSN: | 1879-1891 |
| Popis: | To assess between- and within-individual variability of macular cone topography in the eyes of young adults.Observational case series.Cone photoreceptors in 40 eyes of 20 subjects aged 19-29 years with normal maculae were imaged using a research adaptive optics scanning laser ophthalmoscope. Refractive errors ranged from -3.0 diopters (D) to 0.63 D and differed by0.50 D in fellow eyes. Cone density was assessed on a 2-dimensional sampling grid over the central 2.4 mm × 2.4 mm. Between-individual variability was evaluated by coefficient of variation (COV). Within-individual variability was quantified by maximum difference and root mean square (RMS). Cones were cumulated over increasing eccentricity.Peak densities of foveal cones are 168 162 ± 23 529 cones/mm(2) (mean ± SD) (COV = 0.14). The number of cones within the cone-dominated foveola (0.8-0.9 mm diameter) is 38 311 ± 2319 (COV = 0.06). The RMS cone density difference between fellow eyes is 6.78%, and the maximum difference is 23.6%. Mixed-model statistical analysis found no difference in the association between eccentricity and cone density in the superior/nasal (P = .8503), superior/temporal (P = .1551), inferior/nasal (P = .8609), and inferior/temporal (P = .6662) quadrants of fellow eyes.New instrumentation imaged the smallest foveal cones, thus allowing accurate assignment of foveal centers and assessment of variability in macular cone density in a large sample of eyes. Though cone densities vary significantly in the fovea, the total numbers of foveolar cones are very similar both between and within subjects. Thus, the total number of foveolar cones may be an important measure of cone degeneration and loss. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect