Very low prevalence of anti-HAV in Japan: high potential for future outbreak
| Autor: | Kazuaki Takahashi, Junko Tanaka, Masayuki Ohisa, Toshiko Fujii, Keiko Katayama, Shintaro Nagashima, Takayuki Harakawa, Ko Ko, Chikako Yamamoto, Hiroaki Okamoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male Sanitation Adolescent viruses Population lcsh:Medicine Hepatitis A Antibodies Article Disease Outbreaks 03 medical and health sciences 0302 clinical medicine Japan Risk Factors Seroepidemiologic Studies Environmental health Health care Prevalence Medicine Humans Serologic Tests lcsh:Science education High potential Aged Aged 80 and over education.field_of_study Multidisciplinary business.industry lcsh:R Outbreak virus diseases Hepatitis A Middle Aged digestive system diseases 030104 developmental biology Cohort lcsh:Q Female Hepatitis A virus Anti hav business Developed country 030217 neurology & neurosurgery Hepatitis A Virus Human |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-5 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Since the early 21st century, almost all developed countries have had a very low hepatitis A virus antibody (anti-HAV) sero-prevalence profile, as sanitation conditions and health care facilities have been optimized to a universal standard. There has not been a report on anti-HAV prevalence among a large scale population in Japan since 2003. Therefore, this study aimed to investigate the current HAV status among the general population in Hiroshima. From each age and sex specific group, a total of 1,200 samples were randomly selected from 7,682 stocked serum samples from residents’ and employees’ annual health check-ups during 2013–2015. Total anti-HAV was detected using Chemiluminescent Enzyme Immunoassay. The overall anti-HAV sero-prevalence was 16.8%. In both males and females, anti-HAV prevalence among individuals between 20–59 years of age was as low as 0.0–2.0%, whilst that among 70 s was as high as 70.0–71.0%. A large number of residents aged under 60 are now susceptible to HAV infection. The cohort reduction trend of anti-HAV in Japan exposes the high possibility of mass outbreak in the future. HAV vaccine especially to younger generation and high risk population may prevent outbreak in Japan. |
| Databáze: | OpenAIRE |
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