Small distances can keep bacteria at bay for days

Autor: van Bunnik, Bram A D, Ssematimba, Amos, Hagenaars, Thomas J, Nodelijk, Gonnie, Haverkate, Manon R, Bonten, Marc J M, Hayden, Mary K, Weinstein, Robert A, De Jong, Mart C M, Bootsma, Martin C J, Sub Mathematical Modeling, Mathematical Modeling
Přispěvatelé: Sub Mathematical Modeling, Mathematical Modeling
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Time Factors
Transmission delay
Kwantitatieve Veterinaire Epidemiologie
Diagnostics & Crisis Organization
law.invention
Diffusion
law
Models
Campylobacter Infections
uk
Pathogen
Escherichia coli Infections
Infectivity
Zoonotic bacteria
Cross Infection
Multidisciplinary
Diagnostiek & Crisisorganisatie
biology
Ecology
dynamics
Biological Sciences
Intensive Care Units
Transmission (mechanics)
ASG Infectieziekten
impact
indirect transmission
Biological system
CVI - Division Virology
Infectious agent
Indirect Transmission
Longevity
Models
Biological

Transmission experiment
Campylobacter jejuni
CVI - Divisie Virologie
Species Specificity
Escherichia coli
Animals
Humans
care
Gram-Positive Bacterial Infections
model
broilers
Diffusion model
Quantitative Veterinary Epidemiology
campylobacter
Vancomycin Resistance
biology.organism_classification
Biological
foot
WIAS
Chickens
mouth epidemic
Bacteria
Enterococcus
Zdroj: Proceedings of the National Academy of Sciences of the United States of America, 111(9), 3556. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 111(9), 3556-3560
Proceedings of the National Academy of Sciences of the United States of America 111 (2014) 9
ISSN: 0027-8424
Popis: Transmission of pathogens between spatially separated hosts, i.e., indirect transmission, is a commonly encountered phenomenon important for epidemic pathogen spread. The routes of indirect transmission often remain untraced, making it difficult to develop control strategies. Here we used a tailor-made design to study indirect transmission experimentally, using two different zoonotic bacteria in broilers. Previous experiments using a single bacterial species yielded a delay in the onset of transmission, which we hypothesized to result from the interplay between diffusive motion of infectious material and decay of infectivity in the environment. Indeed, a mathematical model of diffusive pathogen transfer predicts a delay in transmission that depends both on the distance between hosts and on the magnitude of the pathogen decay rate. Our experiments, carried out with two bacterial species with very different decay rates in the environment, confirm the difference in transmission delay predicted by the model. These results imply that for control of an infectious agent, the time between the distant exposure and the infection event is important. To illustrate how this can work we analyzed data observed on the spread of vancomycin-resistant Enterococcus in an intensive care unit. Indeed, a delayed vancomycin-resistant Enterococcus transmission component was identified in these data, and this component disappeared in a study period in which the environment was thoroughly cleaned. Therefore, we suggest that the impact of control strategies against indirect transmission can be assessed using our model by estimating the control measures' effects on the diffusion coefficient and the pathogen decay rate.
Databáze: OpenAIRE