Optimization of Surface-Enhanced Raman Spectroscopy Conditions for Implementation into a Microfluidic Device for Drug Detection
| Autor: | Neal D. Kline, Jason A. Guicheteau, Ian J. Pardoe, Martin Moskovits, Augustus W. Fountain, Ashish Tripathi, Steven D. Christesen, Rustin Y. Mirsafavi, Carl D. Meinhart |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Analyte
Silver Surface Properties Microfluidics Nanoparticle Metal Nanoparticles Nanotechnology 02 engineering and technology Spectrum Analysis Raman 01 natural sciences Analytical Chemistry Methamphetamine Drug detection symbols.namesake Cocaine Limit of Detection Lab-On-A-Chip Devices Humans Anesthetics Local Detection limit Excitation wavelength Morphine Chemistry 010401 analytical chemistry Surface-enhanced Raman spectroscopy 021001 nanoscience & nanotechnology 0104 chemical sciences Analgesics Opioid Substance Abuse Detection symbols Central Nervous System Stimulants Gold 0210 nano-technology Raman spectroscopy |
| Zdroj: | Analytical chemistry. 88(21) |
| ISSN: | 1520-6882 |
| Popis: | A microfluidic device is being developed by University of California-Santa Barbara as part of a joint effort with the United States Army to develop a portable, rapid drug detection device. Surface-enhanced Raman spectroscopy (SERS) is used to provide a sensitive, selective detection technique within the microfluidic platform employing metallic nanoparticles as the SERS medium. Using several illicit drugs as analytes, the work presented here describes the efforts of the Edgewood Chemical Biological Center to optimize the microfluidic platform by investigating the role of nanoparticle material, nanoparticle size, excitation wavelength, and capping agents on the performance, and drug concentration detection limits achievable with Ag and Au nanoparticles that will ultimately be incorporated into the final design. This study is particularly important as it lays out a systematic comparison of limits of detection and potential interferences from working with several nanoparticle capping agents-such as tannate, citrate, and borate-which does not seem to have been done previously as the majority of studies only concentrate on citrate as the capping agent. Morphine, cocaine, and methamphetamine were chosen as test analytes for this study and were observed to have limits of detection (LOD) in the range of (1.5-4.7) × 10 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|