Polymorphic variation in CHAT gene modulates general cognitive ability: An association study with random student cohort
| Autor: | Yuanyu Shi, Jian Wang, Zhe Ma, Fuchang Zhang, Zhangyan Shi, Xu Liu, Xiaocai Gao, Junlin Li, Kejin Zhang, Binbin Niu, Pingyuan Gong, Anyun Zheng |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Adolescent Genotype Choline O-Acetyltransferase Developmental psychology Cohort Studies Young Adult 03 medical and health sciences Cognition Sex Factors 0302 clinical medicine Raven's Progressive Matrices Humans Young adult Students Association (psychology) Genetic Association Studies Multiple choice General Neuroscience 030104 developmental biology Cohort Female Analysis of variance Psychology 030217 neurology & neurosurgery Clinical psychology Cohort study |
| Zdroj: | Neuroscience Letters. 617:122-126 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2016.02.002 |
| Popis: | The choline O-acetyltransferase (CHAT) gene has been associated with various human disorders that involve cognitive impairment or deficiency. However, the influence of disease-associated variants of CHAT on normal individuals remains dubious. Here we demonstrated the impact of CHAT sequence variants (G-120A) on general human cognitive ability in a cohort of 750 Chinese undergraduate students. A multiple choice questionnaire was used to obtain basic demographic information, such as parents' occupations and education levels. We also administered and scored the Raven's Standard Progressive Matrices (RSPM). A one-way analysis of variance (ANOVA) and Kruskal-Wallis test (K-W) revealed a significant association between sequence polymorphisms of G-120A and individuals' Raven score (p=0.031 for ANOVA and p=0.026 for K-W tests). Moreover, further hierarchical analysis showed a similar trend in the association between G-120A variants and Raven scores only in the female subjects (p=0.008 for ANOVA and p=0.024 for K-W tests) but not in the male subjects. The results of a multiple linear regression confirmed that after we controlled gender, age, birthplace and other non-genetic factors, CHAT G-120A polymorphisms still significantly influenced individual Raven scores (B=-0.70, SE=0.28, t=-2.50, p=0.013). Our results demonstrated that sequence variants of CHAT were associated with human cognitive ability in not only patients with psychiatric disorders but also normal healthy individuals. However, some issues remained indeterminable, such as gender differences and the extent of the influence on individuals' general cognitive abilities; thus, the further research using an independent random sample was required. |
| Databáze: | OpenAIRE |
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