Regional mapping of the gene encoding dihydroorotate dehydrogenase, an enzyme involved in UMP synthesis, electron transport, and superoxide generation, to human chromosome region 16q22
| Autor: | Preston Parry, Carol Jones, Tristan S. Barnes, Michele Minet, Iris Hart, David Patterson |
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| Rok vydání: | 1993 |
| Předmět: |
Oxidoreductases Acting on CH-CH Group Donors
Molecular Sequence Data Dihydroorotate Dehydrogenase Biology Dihydroorotate Oxidase Polymerase Chain Reaction Electron Transport Gene mapping Superoxides Genetics Humans Chromosomes Artificial Yeast Gene In Situ Hybridization Fluorescence DNA Primers chemistry.chemical_classification Base Sequence Chromosome Mapping Cell Biology General Medicine Metabolic pathway Enzyme Biochemistry chemistry Chromosomal region Dihydroorotate dehydrogenase Oxidoreductases Uridine Monophosphate Uracil nucleotide Chromosomes Human Pair 16 |
| Zdroj: | Somatic Cell and Molecular Genetics. 19:405-411 |
| ISSN: | 1572-9931 0740-7750 |
| DOI: | 10.1007/bf01232751 |
| Popis: | De novo UMP synthesis is a critical metabolic pathway for nucleic acid synthesis and for a variety of metabolic pathways. The pathway is a target for many widely used cancer chemotherapy agents, several of which are pyrimidine analogs. Humans and cattle have been described with mutations in UMP synthesis that lead to serious inborn errors of metabolism. Dihydroorotate dehydrogenase (EC 1.3.3.1) (DHODH) carries out the fourth committed step in the pathway and may also be important for mitochondrial electron transport and oxygen radical metabolism. We report here that the gene encoding this enzyme in humans is located in the chromosomal region 16q22. With the mapping of DHODH, the mapping of all the steps of UMP synthesis is complete. All three genes involved map to different human chromosomes. This information is important in consideration of regulation of UMP synthesis in mammals, including humans. |
| Databáze: | OpenAIRE |
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