Epileptic Patient with Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy (MOGHE): A Case Report and Review of the Literature
Autor: | Athanasia Alexoudi, Anastasia Verentzioti, S. Gatzonis, Damianos P. Sakas, Ingmar Blümcke, Stefanos Korfias, Panayiotis Patrikelis, Anna Siatouni |
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Rok vydání: | 2019 |
Předmět: |
0303 health sciences
medicine.medical_specialty business.industry Case Report Fluid-attenuated inversion recovery Hyperplasia Malformation of cortical development medicine.disease lcsh:RC346-429 White matter 03 medical and health sciences Epilepsy 0302 clinical medicine medicine.anatomical_structure Frontal lobe medicine Seizure control Epilepsy surgery Radiology General Agricultural and Biological Sciences business lcsh:Neurology. Diseases of the nervous system 030217 neurology & neurosurgery 030304 developmental biology |
Zdroj: | Case Reports in Neurological Medicine, Vol 2019 (2019) Case Reports in Neurological Medicine |
ISSN: | 2090-6676 2090-6668 |
Popis: | Introduction. There is an emerging interest in the literature about MOGHE (Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy). We report the case of an epileptic patient with MOGHE. Case Report. A 33-year-old male patient was suffering from refractory focal epilepsy since adolescence. MRI demonstrated increased T2/FLAIR signal intensity of right frontal lobe. Presurgical evaluation led to definition of epileptogenic network in a specific area of right frontal lobe. The resected specimen revealed MOGHE. Discussion. MOGHE appears to be a brain entity which shares some unique histopathological features. Review of the literature is in accordance with our patient’s findings. The major neuropathological finding consists of areas with blurred gray-white matter boundaries due to heterotopic neurons in white matter and increased numbers of subcortical oligodendroglial cells with increased proliferation. MR abnormalities are present in T2/FLAIR sequences. It concerns patients with refractory frontal lobe epilepsy and appears to associate with unfavourable postsurgical outcome in seizure control. Conclusion. More cases are needed in order to establish more data about this distinct entity in frontal lobe epilepsy. This could be valuable knowledge to patients and doctors concerning expectations or management of undesirable outcome in frontal lobe epilepsy surgery. |
Databáze: | OpenAIRE |
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