Role of the microtubule-associated TPPP/p25 in Parkinson’s and related diseases and its therapeutic potential
| Autor: | Gonçalves, Vinicius O.O., Ciotonea, Carmen, Arrii-Clacens, Sandrine, Guignard, Nadia, Roudaut, Christelle, Rousseau, Julie, Clacens, Jean-Marc, Royer, Sebastien, Richard, Frédéric, Oláh, Judit, Bertrand, Philippe, Ovadi, Judit |
|---|---|
| Přispěvatelé: | Institut de Chimie des Milieux et Matériaux de Poitiers (IC2MP), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Poitiers-Institut de Chimie du CNRS (INC), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, Centre Technique des Applications du Soudage (CTAS), Air Liquide [Siège Social], Environnements et Paléoenvironnements OCéaniques (EPOC), Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institute of Enzymology [Budapest], Research Centre for Natural Sciences, Hungarian Academy of Sciences (MTA)-Hungarian Academy of Sciences (MTA), Université de Poitiers-Institut national des sciences de l'Univers (INSU - CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-École Pratique des Hautes Études (EPHE) |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Multiple Sclerosis Drug target Nerve Tissue Proteins Disease Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Microtubule medicine Humans Molecular Biology ComputingMilieux_MISCELLANEOUS Cell Proliferation Neurons Regulation of gene expression Synucleinopathies Multiple sclerosis Brain Cancer Parkinson Disease Glioma [CHIM.CATA]Chemical Sciences/Catalysis Multiple System Atrophy medicine.disease female genital diseases and pregnancy complications eye diseases 3. Good health Oligodendroglia 030104 developmental biology Gene Expression Regulation Cancer development Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Expert Review of Proteomics Expert Review of Proteomics, Taylor & Francis, 2017, 14 (4), pp.301-309. ⟨10.1080/14789450.2017.1304216⟩ Expert Review of Proteomics, 2017, 14 (4), pp.301-309. ⟨10.1080/14789450.2017.1304216⟩ |
| ISSN: | 1744-8387 1478-9450 |
| Popis: | The discovery and development of therapeutic strategies for the treatments of Parkinson's disease (PD) and other synucleinopathies are limited by a lack of understanding of the pathomechanisms and their connection with different diseases such as cancers. Areas covered: The hallmarks of these diseases are frequently multifunctional disordered proteins displaying moonlighting and/or chameleon features, which are challenging drug targets. A representative of these proteins is the disordered Tubulin Polymerization Promoting Protein (TPPP/p25) expressed specifically in oligodendrocytes (OLGs) in normal brain. Its non-physiological level is tightly related to the etiology of PD and Multiple System Atrophy (TPPP/p25 enrichment in inclusions of neurons and OLGs, respectively), multiple sclerosis (TPPP/p25-positive OLG destruction), as well as glioma (loss of TPPP/p25 expression). The established anti-proliferative potency of TPPP/p25 may raise its influence in cancer development. The recognition that whereas too much TPPP/p25 could kill neurons in PD, but its loss keeps cells alive in cancer could contribute to our understanding of the interrelationship of 'TPPP/p25 diseases'. Expert commentary: The knowledge accumulated so far underlines the key roles of the multifunctional TPPP/p25 in both physiological and diverse pathological processes, consequently its validation as drug target sorely needs a new innovative strategy that is briefly reviewed here. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|