Low-dose GH supplementation reduces the TLR2 and TNF-α expressions in visceral fat
| Autor: | Naoaki Rikihisa, Akikazu Udagawa, Shinya Yoshimoto, Hideaki Bujo, Masaharu Ichinose, Yoshitaka Kubota, Yasushi Saito, Hiroyuki Unoki |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Population Biophysics Intra-Abdominal Fat Growth hormone Biochemistry Mice chemistry.chemical_compound Insulin resistance 3T3-L1 Cells Internal medicine Adipocyte medicine Animals Humans Obesity RNA Messenger education Molecular Biology Visceral fat education.field_of_study Tumor Necrosis Factor-alpha Cell Biology medicine.disease Animal Feed Toll-Like Receptor 2 TLR2 Endocrinology Gene Expression Regulation chemistry Growth Hormone Tumor necrosis factor alpha |
| Zdroj: | Biochemical and Biophysical Research Communications. 368:81-87 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2008.01.035 |
| Popis: | The increased population of TLR2/TNF-alpha co-expressing adipocytes is associated with the development of insulin resistance. We have herein shown the significance of low-dose growth hormone (GH) supplementation for the regulation of TLR2 and TNF-alpha expressions in visceral fat using different kinds of mouse models fed with a high-fat diet. Low-dose GH supplementation reduced the increased population of TLR2/TNF-alpha co-expressing adipocytes in high-fat fed mice. The neutralization of IGF-1 abolished the effect of GH supplementation on the TLR2 expression using GH-overexpressing mice. IGF-1, but not GH, inhibited the FFA-induced TLR2 and TNF-alpha expression in 3T3-L1 cells. Finally, low-dose GH supplementation reduced the TLR2 expression without an obvious change in the visceral fat volume in ob/ob mice. These results indicate that low-dose GH supplementation possibly inhibits the high-fat induced change of the adipocytes to TLR2/TNF-alpha co-expressing cells through the action of IGF-1. |
| Databáze: | OpenAIRE |
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