Desipramine clearance in children and adolescents: absence of effect of development and gender
| Autor: | Jefferson B. Prince, James G. Flood, Stephen V. Faraone, Eric Mick, Joseph Biederman, Timothy E. Wilens, Thomas J. Spencer, Louise Glassner Cohen |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Metabolic Clearance Rate Antidepressive Agents Tricyclic Age and gender Sex Factors Pharmacokinetics Desipramine Internal medicine Developmental and Educational Psychology medicine Humans Desipramina Child Entire population business.industry Age Factors Serum concentration Psychiatry and Mental health Endocrinology Linear Models Female business Pediatric population medicine.drug |
| Zdroj: | Journal of the American Academy of Child and Adolescent Psychiatry. 38(1) |
| ISSN: | 0890-8567 |
| Popis: | Objective To examine the influence of development and gender on the pharmacokinetics of desipramine (DMI) in the pediatric population. Method DMI pharmacokinetic parameters were calculated from 407 routinely drawn, dose- and weight-normalized serum concentrations in 173 youths receiving DMI (90 children, 83 adolescents; 29 were female, 144 were male). Results Mean pharmacokinetic parameters for the entire population included dose (3.78 ± 1.51 mg/kg), weight- and dose-normalized serum concentration (45.41 ± 47.39 [μg/L]/[mg/kg]), and DMI clearance (0.68 ± 1.51 [L/kg]/hr). No between-group differences for children and adolescents were detected in dose (child, adolescent) (3.73 ± 1.40 mg/kg, 3.83 ± 1.68 mg/kg), weight-and dose-normalized serum concentrations (44.52 ± 39.6 [μg/L]/[mg/kg], 46.34 ± 34.89 [μg/L]/[mg/kg]; p = .62). and clearance (0.680 ± 0.890 [L/kg]/hr, 0.695 ± 1.05 [L/kg]/hr; p = .103). No between-group gender differences were detected in dose (male, female) (3.83 ± 1.55 mg, 3.39 ± 1.84 mg), weight-and dose-normalized serum concentrations (45.15 ± 37.76 [μg/L]/[mg/kg]. 47.14 ± 34.96 [μg/L]/[mg/kg]; p = .720). and clearance (0.699 ± 0.89 [L/kg]/hr, 0.606 ± 0.535 [L/kg]/hr; p = .390). Conclusions These results suggest that age and gender do not significantly influence DMI clearance or dose-normalized serum concentrations in the pediatric population. J. Am. Acad. Child Adolesc. Psychiatry. 1999, 38(1):79–85. |
| Databáze: | OpenAIRE |
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