The Effect of Intracoronary Infusion of Autologous Bone Marrow-Derived Lineage-Negative Stem/Progenitor Cells on Remodeling of Post-Infarcted Heart in Patient with Acute Myocardial Infarction

Autor: Ewa Pius-Sadowska, Krzysztof Safranow, Bogusław Machaliński, Edyta Paczkowska, Maciej Kotowski, Zdzisława Kornacewicz-Jach, Jarosław Peregud-Pogorzelski, Krzysztof Przybycień, Małgorzata Peregud-Pogorzelska, Bartłomiej Baumert
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
medicine.medical_specialty
Coronary Artery Disease
Transplantation
Autologous

Ventricular Function
Left

Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Percutaneous Coronary Intervention
Internal medicine
medicine
Humans
Infusions
Intra-Arterial

Myocardial infarction
infarct
Prospective Studies
Progenitor cell
stem/progenitor cells
remodeling
Ejection fraction
lineage-negative cells
Troponin T
Ventricular Remodeling
business.industry
left ventricular failure
General Medicine
Middle Aged
Brain natriuretic peptide
medicine.disease
Combined Modality Therapy
Coronary Vessels
medicine.anatomical_structure
Treatment Outcome
Ventricle
Cardiology
ST Elevation Myocardial Infarction
030211 gastroenterology & hepatology
Female
Stem cell
business
Research Paper
Follow-Up Studies
Stem Cell Transplantation
Zdroj: International Journal of Medical Sciences
ISSN: 1449-1907
Popis: Introduction: Regenerative capacity of the heart is limited, and the post-infarct left ventricle (LV) dysfunction is associated with poor prognosis. Administration of stem/progenitor cells (SPCs) is a promising approach for cardiac regeneration. Objectives: In the study, we assessed LV function and post-infarcted remodeling in patients with ST-elevated myocardial infarct (STEMI) who received autologous lineage-negative (LIN-) SPCs. Patients and methods: Patients with STEMI and one-vessel coronary artery disease treated with percutaneous revascularisation were divided into study group (LIN- group, 15 patients) that received standard therapy and autologous BM-derived LIN- SPCs and control group (standard therapy group, 19 patients). The cells were administered intracoronary 24 hours after STEMI. The follow-up was 12 months with subsequent non-invasive tests and laboratory parameter evaluation on days 1st, 3rd, and 7th as well as at 1st, 3rd, 6th and 12th month after STEMI. Results: All procedures related to SPCs administration were well tolerated by the patients. In 12-month follow-up, there were no major adverse cardiac events connected with LIN- SPCs administration. During 12-month follow-up, 9 patients from LIN- group (Responders) achieved an improvement in LV ejection fraction (>10% after 12 months) with no signs of unfavorable LV remodeling. Laboratory parameters analysis showed that Troponin T levels were significantly lower until day 7th in the Responders group, while brain natriuretic peptide (BNP) level remained significantly lower from day 3rd to 12th month respectively. Conclusions: Intracoronary infusion of autologous BM-derived LIN- stem/progenitor cells is feasible and safe for patient. Improvement in LV function and prevention of unfavorable remodeling in the 60% of study group seems relatively promising. Stem cell-based therapy for cardiac regeneration still needs more accurate and extensive investigations to estimate and improve their efficacy.
Databáze: OpenAIRE