Complement Activation in Patients With Diabetic Nephropathy
Autor: | Celine Q F Klessens, Hans J. Baelde, Ron Wolterbeek, Malu Zandbergen, Pascal Bus, Jan A. Bruijn, Leendert A. Trouw, Cees van Kooten, Jamie S. Chua |
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Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Type 2 diabetes 030204 cardiovascular system & hematology lcsh:RC870-923 Diabetic nephropathy 03 medical and health sciences 0302 clinical medicine Clinical Research renal pathology Diabetes mellitus medicine In patient Clinical significance histological lesions complement activation business.industry diabetic nephropathy medicine.disease lcsh:Diseases of the genitourinary system. Urology C4d Complement system 030104 developmental biology Renal pathology Nephrology business Kidney disease |
Zdroj: | Kidney International Reports, Vol 3, Iss 2, Pp 302-313 (2018) Kidney International Reports Kidney International Reports, 3(2), 302-313 |
Popis: | Introduction Complement activation plays a role in various organs in patients with diabetes. However, in diabetic nephropathy (DN), the role of complement activation is poorly understood. We examined the prevalence and clinical significance of complement deposits in the renal tissue of cases with type 1 and type 2 diabetes with and without DN. Methods We measured the prevalence of glomerular C4d, C1q, mannose-binding lectin (MBL), and C5b-9 deposits in 101 autopsied diabetic cases with DN, 59 autopsied diabetic cases without DN, and 41 autopsied cases without diabetes or kidney disease. The presence of complement deposits was scored by researchers who were blinded with respect to the clinical and histological data. Results C4d deposits were more prevalent in cases with DN than in cases without DN in both the glomeruli (46% vs. 26%) and the arterioles (28% vs. 12%). C1q deposits were also increased in the glomerular hili (77% vs. 55%) and arterioles (33% vs.14%), and were correlated with DN (P < 0.01). MBL deposits were only rarely observed. C5b-9 deposits were more prevalent in the cases with diabetes mellitus (DM) than in the cases without DM (69% vs. 32%; P < 0.001). Finally, glomerular C4d and C5b-9 deposits were correlated with the severity of DN (ρ = 0.341 and 0.259, respectively; P < 0.001). Conclusion Complement activation is correlated with both the presence and severity of DN, suggesting that the complement system is involved in the development of renal pathology in patients with diabetes and is a promising target for inhibiting and/or preventing DN in these patients. |
Databáze: | OpenAIRE |
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