SIRT5 downregulation is associated with poor prognosis in glioblastoma

Autor:	Xue Yang, Wanli Liu, Xiang Wang, Yuanliang Yan, Long Qian, Shuangshuang Zeng, Zhijie Xu, Xi Chen, Jie Wei, Zhicheng Gong, Qiuying Shen
Rok vydání:	2019
Předmět:	Cancer Research SIRT5 Cell Biology medicine.disease_cause Downregulation and upregulation Biomarkers Tumor Genetics medicine Humans Sirtuins 0501 psychology and cognitive sciences Gene 0505 law Integrative bioinformatics Gene Expression Profiling 05 social sciences Computational Biology Genomics General Medicine DNA Methylation Prognosis Gene Expression Regulation Neoplastic medicine.anatomical_structure Oncology DNA methylation 050501 criminology Cancer research CpG Islands NAD+ kinase Glioblastoma Carcinogenesis 050104 developmental & child psychology
Zdroj:	Cancer Biomarkers. 24:449-459
ISSN:	1875-8592 1574-0153
DOI:	10.3233/cbm-182197
Popis:	Objective Sirtuins (SIRT) are NAD+-dependent protein deacetylases that are involved in the regulation of cancer-associated pathways. However, the biological role of these deacetylases remains elusive in glioblastoma (GBM). Here, we evaluated the effects of 7 sirtuins regarding their occurrence and prognostic value for GBM. Methods In this research, the effects of SIRT5 on the occurrence and prognosis of GBM were evaluated using integrative bioinformatics analyses. Results Based on comprehensive analyses of data obtained from web-based bioinformatics platforms, the data demonstrate that only SIRT5 expression is statistically decreased in GBM tissues. The clinical relevance analysis shows that downregulation of SIRT5 is significantly correlated with a shorter survival time. Moreover, the expression levels of SIRT5 were confirmed to be negatively associated with DNA methylation status. In addition, a protein-protein interaction network was constructed to determine the relationship of genes coexpressed with SIRT5. Functional enrichment analysis revealed that SIRT5 was potentially involved in epithelial-mesenchymal transition and in regulating cell communications. Conclusions Collectively, our results indicate that SIRT5 acts as a potential suppresser during tumorigenesis, and suggest that SIRT5 may be a promising prognostic biomarker of GBM.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d01827bfb4a4351c87bfe7c5e54c2fb https://doi.org/10.3233/cbm-182197 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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